中国神经再生研究(英文版)

中国神经再生研究(英文版) ›› 2019, Vol. 14 ›› Issue (12): 2126-2131.doi: 10.4103/1673-5374.262590

• 原著:脑损伤修复保护与再生 • 上一篇    下一篇

基于静息状态功能磁共振成像技术分析国际标准头针常用穴位对脑区的调节作用

  

  • 出版日期:2019-12-15 发布日期:2019-12-15
  • 基金资助:

    中国国际自然科学基金项目（81403455）

Modulatory effect of International Standard Scalp Acupuncture on brain activation in the elderly as revealed by resting-state fMRI

Wai-Yeung Chung 1, 2 , Song-Yan Liu 3 , Jing-Chun Gao 4 , Yi-Jing Jiang 5 , Jing Zhang 3 , Shan-Shan Qu 1 , Ji-Ping Zhang 1 , Xiao-Long Tan 6 , Jun-Qi Chen 4 , Sheng-Xu Wang 1   

  1. 1 School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, Guangdong Province, China
    2 School of Chinese Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong Special Administrative Region, China
    3 Department of Neurology, China-Japan Union Hospital of Jilin University, Changchun, Jilin Province, China
    4 Department of Rehabilitation Medicine, Third Affiliated Hospital of Southern Medical University, Guangzhou, Guangdong Province, China
    5  Department of Rehabilitation Medicine, Rehabilitation Hospital, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian Province, China
    6 Department of Medical Image, Third Affiliated Hospital of Southern Medical University, Guangzhou, Guangdong Province, China
  • Online:2019-12-15 Published:2019-12-15
  • Contact: un-Qi Chen, PhD, meixibao@126.com; Sheng-Xu Wang, PhD, sxwang88@126.com.
  • Supported by:

    This study was funded by the National Natural Science Foundation of China, No. 81403455 (to JQC).

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摘要：

国际标准头针刺激常用穴位顶中线、顶颞前斜线、顶颞后斜线，针刺会引起中枢神经的一些变化，但其具体的机制尚不明确。此次单臂前瞻性临床试验数据在吉林大学中日联谊医院完成，采用国际标准头针针刺7名健康老年志愿者（男3人，女4人，年龄56.14±4.06岁）的MS5（督脉百会穴至前顶穴段）、左侧MS6（头部经外穴前神聪至颞部胆经悬厘联线）以及左侧MS7（督脉百会穴至颞部胆经曲鬓穴联线），以静息态功能磁共振成像技术检测显示，右楔叶以及距状沟和BA17周围低频振幅比率下降，且降低趋势延伸至双侧舌下回、左楔叶、以及距状沟和BA17周围大脑皮质。楔前叶和楔叶局部一致性下降，且降低趋势延伸至距状沟和舌下回周围大脑皮质；同时左侧中央前回和中央后回局部一致性也出现下降，且延伸至左后颞上回(BA41, BA42, BA22)。左前扣带皮质(BA32)局部一致性上升，且向左侧额内侧回和右前扣带皮质延伸；同时在右侧额内侧回（BA46）以及左侧缘上回局部一致性上升。基于左前扣带皮质种子区(-6, 33, -3)的功能连接在左侧辅助运动区下降，且延伸至双侧中央旁小叶、右侧辅助运动区、额内侧回和BA6脑区。基于右侧额中回种子区(42, 51, 9)的功能连接在双侧额内侧回下降。表明国际标准头针组穴针刺可特异性增强健康老年人认知和执行脑网络和周围大脑区域的调节作用。试验于2016年7月18日经中日联谊医院伦理委员会批准，批准号2016ks043，并在中国临床试验注册中心注册，注册号ChiCTR-IOR-15007672。

orcid: 0000-0001-6847-0891(Jun-Qi Chen)
          0000-0001-6670-6346(Sheng-Xu Wang)

关键词: 静息态功能磁共振, 国际标准头针, 穴位特异性, 脑功能连接, 健康老年人, 低频振幅比率, 局部一致性, 功能连接, 神经再生

Abstract:

The specific mechanisms by which acupuncture affects the central nervous system are unclear. In the International Standard Scalp Acupuncture system, acupuncture needles are applied at the middle line of the vertex, anterior parietal-temporal oblique line, and the posterior parietal-temporal oblique line. We conducted a single-arm prospective clinical trial in which seven healthy elderly volunteers (three men and four women; 50–70 years old) received International Standard Scalp Acupuncture at MS5 (the mid-sagittal line between Baihui (DU20) and Qianding (DU21)), the left MS6 (line joining Sishencong (EX-HN1) and Xuanli (GB6)), and the left MS7 (line joining DU20 and Qubin (GB7)). After acupuncture, resting-state functional magnetic resonance imaging demonstrated changes in the fractional amplitude of low frequency fluctuations and regional homogeneity in various areas, showing remarkable enhancement of regional homogeneity in the bilateral anterior cingulate, left medial frontal gyrus, supramarginal gyrus, right middle frontal gyrus, and inferior frontal gyrus. Functional connectivity based on a seed region at the right middle frontal gyrus (42, 51, 9) decreased at the bilateral medial superior frontal gyrus. Our data preliminarily indicates that the international standard scalp acupuncture in healthy elderly participants specifcally enhances the correlation between the brain regions involved in cognition and implementation of the brain network regulation system and the surrounding adjacent brain regions. The study was approved by the Ethics Committee of the China-Japan Union Hospital at Jilin University, China, on July 18, 2016 (approval No. 2016ks043).

Key words: nerve regeneration, resting-state functional magnetic resonance imaging, International Standard Scalp Acupuncture, acupoint specificity, brain functional connectivity, healthy elderly volunteers, low frequency fluctuation, regional homogeneity, functional connectivity, neural regeneration