中国神经再生研究(英文版)

中国神经再生研究(英文版) ›› 2023, Vol. 18 ›› Issue (7): 1542-1547.doi: 10.4103/1673-5374.360244

• 观点:脑损伤修复保护与再生 • 上一篇    下一篇

默认脑功能网络在猴免疫缺陷病毒感染早期即可受到影响：一项纵向研究

  

  • 出版日期:2023-07-15 发布日期:2023-01-12
  • 基金资助:
    国家自然科学基金项目（82271963，81771806，61936013，82001914，81871511）；国家重点研发计划项目（2021YFA1301603）；北京市自然科学基金项目（7212051）

The default mode network is affected in the early stage of simian immunodeficiency virus infection: a longitudinal study#br#

Zhen-Chao Tang1, 2, 3, #, Jiao-Jiao Liu4, #, Xue-Tong Ding1, 2, 3, #, Dan Liu5, Hong-Wei Qiao6, Xiao-Jie Huang4, Hui Zhang1, 2, 3, *, Jie Tian1, 2, 3, *, Hong-Jun Li4, *#br#   

  1. 1Beijing Advanced Innovation Center for Big Data-Based Precision Medicine, School of Engineering Medicine, Beihang University, Beijing, China; 2Key Laboratory of Big Data-Based Precision Medicine (Beihang University), Ministry of Industry and Information Technology of the People’s Republic of China, Beijing, China; 3Key Laboratory of Molecular Imaging, Institute of Automation, Chinese Academy of Sciences, Beijing, China; 4Beijing Youan Hospital, Capital Medical University, Beijing, China; 5Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; 6Institute of Laboratory Animal Sciences, Chinese Academy of Medical Sciences, Beijing, China 
  • Online:2023-07-15 Published:2023-01-12
  • Contact: Hong-Jun Li, MD, lihongjun00113@ccmu.edu.cn; Jie Tian, PhD, tianj@buaa.edu.cn; Hui Zhang, PhD, hui.zhang@buaa.edu.cn.
  • Supported by:
    This study was supported by the National Natural Science Foundation of China, Nos. 82271963 (to HJL), 81771806 (to HJL), 61936013 (to HJL), 82001914 (to ZCT), 81871511 (to HZ); National Key R&D Program of China, No. 2021YFA1301603 (to ZCT); and the Natural Science Foundation of Beijing, No. 7212051 (to HJL). 

PDF

18

摘要：

获得性免疫缺陷综合征感染会导致以默认模式网络变化为代表的认知功能障碍。但是目前研究大多是横断面的，难以揭示默认功能网络随着病毒感染以及联合抗逆转录病毒治疗所引起的动态变化。尤其是当只分析一个时间点的脑影像数据时，无法确定默认功能网络在感染获得性免疫缺陷综合征发生后多久进行联合抗逆转录病毒治疗最为有效。然而受到感染时间不透明等因素影响，直接在临床上开展此类纵向研究并不可行。因此，此次实验对猴免疫缺陷病毒感染恒河猴模型进行有关默认功能网络脑功能网络随时间点的动态变化的纵向研究。结果显示，基线、10d以及4周时，有11对中的默认模式网络连接性发生显著变化，其中area31/V6.R和area8/FEF.L，area8/FEF.L和TPOC.R以及area31/V6.R和TPOC.L的默认模式网络连接中可见治疗与时间存在交互作用。而在4周后开始的联合抗逆转录病毒治疗不仅能中断了猴免疫缺陷病毒感染的进展，而且很大程度上保留了大脑功能。这表明默认模式网络在猴免疫缺陷病毒感染的早期即可受到影响，其可作为脑功能早期变化的潜在生物标志物，会成为有助于临床早期干预决策制定的一项客观指标。

https://orcid.org/0000-0003-2883-4931 (Hui Zhang); 

https://orcid.org/0000-0003-0498-0432 (Jie Tian); 

https://orcid.org/0000-0001-5887-5684 (Hong-Jun Li)

关键词: 猴免疫缺陷病毒, 默认模式网络, 纵向研究, 抗逆转录病毒疗法, 功能磁共振成像, 方差分析, 获得性免疫缺陷综合征, 恒河猴, SIV-mac239, 人免疫缺陷病毒

Abstract: Acquired immune deficiency syndrome infection can lead to cognitive dysfunction represented by changes in the default mode network. Most recent studies have been cross-sectional and thus have not revealed dynamic changes in the default mode network following acquired immune deficiency syndrome infection and antiretroviral therapy. Specifically, when brain imaging data at only one time point are analyzed, determining the duration at which the default mode network is the most effective following antiretroviral therapy after the occurrence of acquired immune deficiency syndrome. However, because infection times and other factors are often uncertain, longitudinal studies cannot be conducted directly in the clinic. Therefore, in this study, we performed a longitudinal study on the dynamic changes in the default mode network over time in a rhesus monkey model of simian immunodeficiency virus infection. We found marked changes in default mode network connectivity in 11 pairs of regions of interest at baseline and 10 days and 4 weeks after virus inoculation. Significant interactions between treatment and time were observed in the default mode network connectivity of regions of interest pairs area 31/V6.R and area 8/frontal eye field (FEF). L, area 8/FEF.L and caudal temporal parietal occipital area (TPOC).R, and area 31/V6.R and TPOC.L. ART administered 4 weeks after infection not only interrupted the progress of simian immunodeficiency virus infection but also preserved brain function to a large extent. These findings suggest that the default mode network is affected in the early stage of simian immunodeficiency virus infection and that it may serve as a potential biomarker for early changes in brain function and an objective indicator for making early clinical intervention decisions.

Key words: acquired immune deficiency syndrome, analysis of variance, antiretroviral therapy, default mode network, functional magnetic resonance imaging, human immunodeficiency virus, longitudinal study, rhesus monkeys, simian immunodeficiency virus, SIV-mac239