中国神经再生研究(英文版)

中国神经再生研究(英文版) ›› 2015, Vol. 10 ›› Issue (5): 760-765.doi: 10.4103/1673-5374.156977

• 原著:脑损伤修复保护与再生 • 上一篇    下一篇

亚急性脑卒中患者脑功能活性变化：神经再生的潜在干预靶点？

  

  • 收稿日期:2015-02-04 出版日期:2015-05-15 发布日期:2015-05-15
  • 基金资助:

    国家自然科学基金(81072864)

Changes of resting cerebral activities in subacute ischemic stroke patients

Ping Wu 1, Fang Zeng 1, Yong-xin Li 2, Bai-li Yu 3, Li-hua Qiu 4, Wei Qin 5, Ji Li 3, Yu-mei Zhou 1, Fan-rong Liang 1   

  1. 1 Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan Province, China
    2 Institute of Clinical Anatomy, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong Province, China
    3 The First Teaching Hospital, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan Province, China
    4 Radiology Department, West China Hospital of Sichuan University, Chengdu, Sichuan Province, China
    5 Life Sciences Research Center, School of Life Sciences and Technology, Xidian University, Xi’an, Shaanxi Province, China
  • Received:2015-02-04 Online:2015-05-15 Published:2015-05-15
  • Contact: Fan-rong Liang, wuping_33@163.com
  • Supported by:

    This study was financially supported by grants from the National Natural Science Foundation of China, No. 81072864 and the Scientific Research Fund of Sichuan Provincial Education Department, No. 12TD002.

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摘要：

探讨缺血性卒中患者与正常人脑区局部的功能活性的差异，确定其异常位点，可为缺血性卒中的干预和疗效评价提供思路和依据，目前关于缺血性脑卒中功能影像的研究对象大部分集中在伴有运动功能障碍的急性期患者。文章利用功能磁共振技术采集静息态的亚急性期(15 d-11.5周)缺血性卒中患者和正常健康人各15例的影像学数据。局部一致性检测分析显示，与正常健康人比较，缺血性卒中患者脑局部功能活性值在前扣带回、左侧脑降低，在小脑左侧楔前叶、左侧额叶增高。结果证实，亚急性缺血性卒中患者与正常人脑区局部的功能活性差异主要体现在小脑、左侧楔前叶、左额下回三角部、左颞下回和前扣带回，主要涉及人体的运动、感觉和认知等区域，作者认为，上述区域可能是亚急性脑卒中患者神经再生潜在的干预靶点。

关键词: 神经再生, 脑损伤, 神经影像, 功能磁共振成像, 脑区局部功能强度值, 局部一致性, 脑卒中, 亚急性, 脑缺血, 被试, 健康者, 志愿者, 脑区功能活性, 国家自然科学基金

Abstract:

This study aimed to detect the difference in resting cerebral activities between ischemic stroke patients and healthy participants, define the abnormal site, and provide new evidence for pathological mechanisms, clinical diagnosis, prognosis prediction and efficacy evaluation of ischemic stroke. At present, the majority of functional magnetic resonance imaging studies focus on the motor dysfunction and the acute stage of ischemic stroke. This study recruited 15 right-handed ischemic stroke patients at subacute stage (15 days to 11.5 weeks) and 15 age-matched healthy participants. A resting-state functional magnetic resonance imaging scan was performed on each subject to detect cerebral activity. Regional homogeneity analysis was used to investigate the difference in cerebral activities between ischemic stroke patients and healthy participants. The results showed that the ischemic stroke patients had lower regional homogeneity in anterior cingulate and left cerebrum and higher regional homogeneity in cerebellum, left precuneus and left frontal lobe, compared with healthy participants. The experimental findings demonstrate that the areas in which regional homogeneity was different between ischemic stroke patients and healthy participants are in the cerebellum, left precuneus, left triangle inferior frontal gyrus, left inferior temporal gyrus and anterior cingulate. These locations, related to the motor, sensory and emotion areas, are likely potential targets for the neural regeneration of subacute ischemic stroke patients.

Key words: nerve regeneration, brain injury, neuroimaging, functional magnetic resonance imaging, regional homogeneity, apoplexy, subacute, ischemia, participants, healthy, volunteers, brain activity, NSFC grants, neural regeneration