中国神经再生研究(英文版) ›› 2024, Vol. 19 ›› Issue (3): 509-511.doi: 10.4103/1673-5374.380900

• 观点:退行性病与再生 • 上一篇    下一篇

靶向tau淀粉样蛋白聚集的小分子

  

  • 出版日期:2024-03-15 发布日期:2023-09-02

Small molecules to target tau amyloid aggregation

Zoe Manglano-Artuñedo, Samuel Peña-Díaz*, Salvador Ventura*#br#   

  1. Institut de Biotecnologia i Biomedicina, Universitat Autònoma de Barcelona, Bellaterra, Spain
  • Online:2024-03-15 Published:2023-09-02
  • Contact: Samuel Peña-Díaz, PhD, Samuel.pdiaz@uab.cat; Salvador Ventura, PhD, Salvador.ventura@uab.cat.
  • Supported by:
    This work was funded by European Union Horizon 2020 research and innovation programme under GA 952334 (PhasAGE), by the Spanish Ministry of Science and Innovation (PID2019-105017RB-I00), and by ICREA, ICREA Academia 2015, and 2020 (to SV).

摘要: https://orcid.org/0000-0002-2902-823X (Samuel Peña-Díaz)

Abstract: Protein aggregation has been linked with many neurodegenerative diseases, such as Alzheimer’s disease (AD) or Parkinson’s disease. AD belongs to a group of heterogeneous and incurable neurodegenerative disorders collectively known as tauopathies. They comprise frontotemporal dementia, Pick’s disease, or corticobasal degeneration, among others. The symptomatology varies with the specific tau protein variant involved and the affected brain region or cell type. However, they share a common neuropathological hallmark - the formation of proteinaceous deposits named neurofibrillary tangles. Neurofibrillary tangles, primarily composed of aggregated tau (Zhang et al., 2022), disrupt normal neuronal functions, leading to cell death and cognitive decline.