中国神经再生研究(英文版) ›› 2024, Vol. 19 ›› Issue (8): 1635-1636.doi: 10.4103/1673-5374.389637

• 观点:脑损伤修复保护与再生 • 上一篇    下一篇

大脑中G蛋白偶联受体信号传导的两性异形

  

  • 出版日期:2024-08-15 发布日期:2024-01-03

Sexual dimorphism of G protein-coupled receptor signaling in the brain

Sara Aljoudi, Hamdan Hamdan, Khaled S. Abd-Elrahman*#br#   

  1. Department of Physiology and Immunology, College of Medicine and Health Sciences, Khalifa University, Abu Dhabi, United Arab Emirates (Aljoudi S, Hamdan H) 
    Healthcare Engineering Innovation Center (HEIC), Khalifa University, Abu Dhabi, United Arab Emirates (Hamdan H) 
    Department of Anesthesiology, Pharmacology and Therapeutics, and Djavad Mowafaghian Center for Brain Health, University of British Columbia, Vancouver, BC, Canada (Abd-Elrahman KS) 
    Department of Pharmacology and Therapeutics, College of Medicine and Health Science, Khalifa University, Abu Dhabi, United Arab Emirates (Abd-Elrahman KS) 
    Department of Pharmacology and Toxicology, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt (Abd-Elrahman KS)
  • Online:2024-08-15 Published:2024-01-03
  • Contact: Khaled S. Abd-Elrahman, PhD, khaled.abdelrahman@ubc.ca.
  • Supported by:
    KSAE is a Michael Smith Health Research BC funded Health-Professional investigator. This work was supported by a New Investigator grant from the Alzheimer’s Society of Canada and Alzheimer Disease Research Grant from Djavad Mowafaghian Centre for Brain Health (to KSAE). 

摘要: https://orcid.org/0000-0001-9724-1975 (Khaled S. Abd-Elrahman)

Abstract: G protein-coupled receptors (GPCRs) represent the most substantial family of membrane receptors that are targeted by U.S. Food and Drug Administration-approved drugs. Much of the preclinical research to understand the pharmacology of many membrane receptors including GPCRs is derived from studies in male animal models (Karp and Reavey, 2019). This can be of concern as emerging evidence reveals unexpected sex-dependent differences in GPCR pharmacodynamics. Thus, understanding the sex-specific disparities in GPCR pharmacological fingerprints can aid in developing targeted ligands that precisely correct GPCR signaling modalities in men and women and ultimately, enhance their effectiveness for certain pathophysiological conditions. We will attempt to summarize the current evidence supporting the sex-biased signaling of GPCRs implicated in several brain disorders.