中国神经再生研究(英文版) ›› 2025, Vol. 20 ›› Issue (7): 1930-1943.doi: 10.4103/NRR.NRR-D-23-01761

• 综述:退行性病与再生 • 上一篇    下一篇

从口腔微生物视角解读脑衰老

  

  • 出版日期:2025-07-15 发布日期:2024-11-26

Unraveling brain aging through the lens of oral microbiota

Qinchao Hu1, 2, Si Wang3, 4, *, Weiqi Zhang5, 6, 7, 8, *, Jing Qu6, 7, 8, 9, 10, *, Guang-Hui Liu1, 3, 4, 6, 7, 8, 10, *   

  1. 1 State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China;  2 Hospital of Stomatology, Guanghua School of Stomatology, Guangdong Provincial Key Laboratory of Stomatology, Sun Yat-sen University, Guangzhou, Guangdong Province, China;  3 Advanced Innovation Center for Human Brain Protection and National Clinical Research Center for Geriatric Disorders, Xuanwu Hospital, Capital Medical University, Beijing, China;  4 Aging Translational Medicine Center, International Center for Aging and Cancer, Beijing Municipal Geriatric Medical Research Center, Xuanwu Hospital, Capital Medical University, Beijing, China;  5 CAS Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences and China National Center for Bioinformation, Beijing, China;  6 University of Chinese Academy of Sciences, Beijing, China;  7 Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, China;  8 Aging Biomarker Consortium, Beijing, China;  9 State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China;  10 Beijing Institute for Stem Cell and Regenerative Medicine, Beijing, China
  • Online:2025-07-15 Published:2024-11-26
  • Contact: Si Wang, PhD, wangsi@xwh.ccmu.edu.cn; Weiqi Zhang, PhD, zhangwq@big.ac.cn; Jing Qu, PhD, qujing@ioz.ac.cn; Guang-Hui Liu, PhD, ghliu@ioz.ac.cn.
  • Supported by:
    This work was supported by the National Natural Science Foundation of China, No. 81921006 (to GHL).

摘要:

口腔是一个复杂的生态群落,包含了大量的微生物。口腔微生物群失调会导致多种口腔疾病,如牙周炎和蛀牙,甚至影响人体健康,包括脑衰老,从而导致神经退行性疾病。最近有研究揭示了口腔微生物如何参与脑衰老和神经退行性变,这为干预策略指明了潜在途径。此次综述总结了口腔微生物/口腔感染性疾病与脑衰老/神经退行性疾病之间联系的临床证据;进而剖析了口腔微生物促进脑衰老和神经退行性变的分子机制;最后强调了从口腔微生物视角开发的延缓脑衰老或神经退行性变的干预策略。该项综述为从口腔微生物视角解析脑衰老提供了参考,同时也对老年人或神经退行性疾病患者的健康管理提供了新的指导——开展口腔健康教育,因而帮助老年人或神经退行性疾病患者做好口腔卫生管理具有重要意义。

https://orcid.org/0000-0003-2431-0612 (Si Wang); https://orcid.org/0000-0002-8885-5104 (Weiqi Zhang); 

https://orcid.org/0000-0002-3988-5067 (Jing Qu); https://orcid.org/0000-0001-9289-8177 (Guang-Hui Liu)

关键词: 脑衰老, 口腔微生物, 神经退行性疾病, 神经退行性变, 牙周炎, 细菌, 牙龈卟啉单胞菌, 阿尔茨海默病, 帕金森病, 多发性硬化

Abstract: The oral cavity is a complex physiological community encompassing a wide range of microorganisms. Dysbiosis of oral microbiota can lead to various oral infectious diseases, such as periodontitis and tooth decay, and even affect systemic health, including brain aging and neurodegenerative diseases. Recent studies have highlighted how oral microbes might be involved in brain aging and neurodegeneration, indicating potential avenues for intervention strategies. In this review, we summarize clinical evidence demonstrating a link between oral microbes/oral infectious diseases and brain aging/neurodegenerative diseases, and dissect potential mechanisms by which oral microbes contribute to brain aging and neurodegeneration. We also highlight advances in therapeutic development grounded in the realm of oral microbes, with the goal of advancing brain health and promoting healthy aging.

Key words: Alzheimer’s disease, brain aging, multiple sclerosis, neurodegeneration, neurodegenerative diseases, oral microbiota, Parkinson’s disease, periodontitis, bacteria, Porphyromonas gingivalis