中国神经再生研究(英文版) ›› 2025, Vol. 20 ›› Issue (6): 1703-1704.doi: 10.4103/NRR.NRR-D-24-00324

• 观点:神经损伤修复保护与再生 • 上一篇    下一篇

单细胞泛组学、环境神经病学和人工智能:全面脑健康研究的时代

  

  • 出版日期:2025-06-15 发布日期:2024-11-12

Single-cell pan-omics, environmental neurology, and artificial intelligence: the time for holistic brain health research

Paolo Abondio* , Francesco Bruno   

  1. IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy (Abondio P) Association for Neurogenetic Research (ARN), Lamezia Terme, Catanzaro, Italy (Bruno F)
  • Online:2025-06-15 Published:2024-11-12
  • Contact: Paolo Abondio, PhD, paolo.abondio2@unibo.it.

摘要: https://orcid.org/0000-0002-9626-8495 (Paolo Abondio)

Abstract: The brain, with its trillions of neural connections, d i ffe re n t c e l l u l a r t y p e s , a n d m o l e c u l a r complexities, presents a formidable challenge for researchers aiming to comprehend the multifaceted nature of neural health. As traditional methods have provided valuable insights, emerging technologies offer unprecedented o p p o r t u n i t i e s to d e l v e d e e p e r i nt o t h e underpinnings of brain function. In the everevolving landscape of neuroscience, the quest to unravel the mysteries of the human brain is bound to take a leap forward thanks to new technological improvements and bold interpretative frameworks. Indeed, as our understanding of the intricacies of the human brain advances, so does the need for comprehensive and integrative approaches to studying brain health in a synergistic manner, bridging the gap between biology (e.g., molecular pathways), interactions (e.g., environmental influences), and advanced computational analyses (e.g., explainable artificial intelligence). Brain health, therefore, is not just about understanding brain function in and of itself; it is about comprehending its complex relational networks with the surrounding environment (represented by physiological, psychological, or external stimuli) and putting this information at the service of personalized well-being through precision medicine.