中国神经再生研究(英文版) ›› 2025, Vol. 20 ›› Issue (11): 3227-3228.doi: 10.4103/NRR.NRR-D-24-00760

• 观点:退行性病与再生 • 上一篇    下一篇

中枢神经系统中驻留记忆 T 细胞连接神经炎症和神经退行性疾病

  

  • 出版日期:2025-11-15 发布日期:2025-02-23

Role of resident memory T cells in neuroinflammatory and neurodegenerative diseases in the central nervous system

Kimitoshi Kimura*   

  1. Department of Neurology, Kyoto University Graduate School of Medicine, Tokyo, Japan; Department of Immunology, National Center of Neurology and Psychiatry, Tokyo, Japan
  • Online:2025-11-15 Published:2025-02-23
  • Contact: Kimitoshi Kimura, MD, PhD, kimura@kuhp.kyoto-u.ac.jp.

摘要: https://orcid.org/0000-0002-8359-2886 (Kimitoshi Kimura)

Abstract: The immune system has been attracting increasing attention in the field of chronic neurological disorders in the central nervous system (CNS). Autoreactive T cells targeting CNS antigens play a crucial role in the development of various autoimmune diseases, such as multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD). Moreover, T cells are now recognized as a pivotal contributor to the pathology of neurodegenerative disorders, including Alzheimer’s disease (AD), Parkinson’s disease (PD), and multiple system atrophy. Among the diverse array of T cell subsets, resident memory T (Trm) cells are suspected to exert a substantial influence on the progression of these debilitating diseases. Trm cells are distinguished by their restricted localization within tissues and their unique transcriptomic signature. This perspective aims to elucidate the current understanding of Trm cells in CNS disorders and to explore future directions in this rapidly evolving field.