中国神经再生研究(英文版)

中国神经再生研究(英文版) ›› 2012, Vol. 7 ›› Issue (3): 191-196.

• 原著:脑损伤修复保护与再生 • 上一篇    下一篇

Effects of Yulangsan polysaccharide on monoamine neurotransmitters, adenylate cyclase activity and brain-derived neurotrophic factor expression in a mouse model of depression induced by unpredictable chronic mild stress

  

  • 收稿日期:2011-09-12 修回日期:2011-12-14 出版日期:2012-01-25 发布日期:2012-01-25

Effects of Yulangsan polysaccharide on monoamine neurotransmitters, adenylate cyclase activity and brain-derived neurotrophic factor expression in a mouse model of depression induced by unpredictable chronic mild stress

Shuang Liang, Renbin Huang, Xing Lin, Jianchun Huang, Zhongshi Huang, Huagang Liu   

  1. Department of Pharmacology, College of Pharmacy, Guangxi Medical University, Nanning 530021, Guangxi Zhuang Autonomous Region, China
  • Received:2011-09-12 Revised:2011-12-14 Online:2012-01-25 Published:2012-01-25
  • Contact: Renbin Huang, Doctor, Professor, Doctoral supervisor, Department of Pharmacology, College of Pharmacy, Guangxi Medical University, Nanning 530021, Guangxi Zhuang Autonomous Region, China huangrenbin518@163.com
  • About author:Shuang Liang☆, Doctor, Department of Pharmacology, College of Pharmacy, Guangxi Medical University, Nanning 530021, Guangxi Zhuang Autonomous Region, China

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Abstract:

The present study established a mouse model of depression induced by unpredictable chronic mild stress. The model mice were treated with Yulangsan polysaccharide (YLSPS; 150, 300 and 600 mg/kg) for 21 days, and compared with fluoxetine-treated and normal control groups. Enzyme-linked immunosorbent assay, radioimmunity and immunohistochemical staining showed that following treatment with YLSPS (300 and 600 mg/kg), monoamine neurotransmitter levels, prefrontal cortex adenylate cyclase activity and hippocampal brain-derived neurotrophic factor expression were significantly elevated, and depression-like behaviors were improved. Open-field and novelty-suppressed feeding tests showed that mouse activity levels were increased and feeding latency was shortened following treatment. Our results indicate that YLSPS inhibits depression by upregulating monoamine neurotransmitters, prefrontal cortex adenylate cyclase activity and hippocampal brain-derived neurotrophic factor expression.

Key words: Yulangsan polysaccharide, anti-depressant, chronic stress, monoamine neurotransmitter, adenylate cyclase, brain-derived neurotrophic factor, Chinese medicine, neural regeneration