中国神经再生研究(英文版)

中国神经再生研究(英文版) ›› 2012, Vol. 7 ›› Issue (4): 268-272.

• 原著:颅神经损伤修复保护与再生 • 上一篇    下一篇

A quantitative study on changes of the myelinated fibers in the cerebral cortex of cortical dysplasia rats

  

  • 收稿日期:2011-09-24 修回日期:2011-12-22 出版日期:2012-02-05 发布日期:2012-02-05

A quantitative study on changes of the myelinated fibers in the cerebral cortex of cortical dysplasia rats

Xuntai Ma1, Yong Tang2, 3, Yang Lv4, Oumei Cheng3, Yong Yan3   

  1. 1 Department of Neurology, Affiliated Hospital of Luzhou Medical College, Luzhou 646000, Sichuan Province, China
    2 Department of Histology and Embryology, Institute of Basic Medical Sciences, Chongqing Medical University, Chongqing 400016, China
    3 Department of Neurology, the First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China
    4 Department of Geriatrics, the First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China
  • Received:2011-09-24 Revised:2011-12-22 Online:2012-02-05 Published:2012-02-05
  • Contact: Xuntai Ma, Department of Neurolo-gy, Affiliated Hospital of Luzhou Medical College, Luzhou 646000, Sichuan Province, China maxuntai2002@126.com
  • About author:Xuntai Ma☆, M.D., Associate professor, Associate chief physician, Master’s supervi-sor, Department of Neurolo-gy, Affiliated Hospital of Luzhou Medical College, Luzhou 646000, Sichuan Province, China

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Abstract:

An animal model of cortical dysplasia was established through X-ray irradiation induced subcortical heterotopic nodules in rats. Transmission electron microscopy detection of the ultrastructure and the stereology examination showed that there was a significant decrease in cerebral white matter and hippocampal volume, the total volume, volume density, length density and total length of the myelinated fibers in the white matter of cortical dysplasia rats. Subcortical heterotopic nodules of the hippocampal CA1 region and synaptic number density in the CA3 region were reduced compared with normal rats. Our experimental findings indicate that erosed subcortical heterotopic nodules, decreased total length of myelinated nerve fibers and demyelination directly lead to a reduction of white matter volume.

Key words: cortical dysplasia, heterotopic nodules, white matter, myelinated fibers, medullary sheath, stereology