中国神经再生研究(英文版) ›› 2015, Vol. 10 ›› Issue (10): 1678-1682.doi: 10.4103/1673-5374.167769

• 原著:周围神经损伤修复保护与再生 • 上一篇    下一篇

炎症和皮肤神经系统参与了增生性瘢痕的形成

  

  • 收稿日期:2015-06-15 出版日期:2015-10-28 发布日期:2015-10-28
  • 基金资助:

    山东省医学科技发展项目(2014WS0354);国家自然科学基金项目(81272099);山东省医学与健康科技发展基金青年项目(2009QZ023);山东省自然科学基金项目(BS2009YY043)

Inflammation and cutaneous nervous system involvement in hypertrophic scarring

Shao-hua Li1, Heng-lian Yang2, Hu Xiao1, *, Yi-bing Wang1, De-chang Wang1, Ran Huo1   

  1. 1 Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong Province, China
    2 Jinan Fire Protection Hospital, Jinan, Shandong Province, China
  • Received:2015-06-15 Online:2015-10-28 Published:2015-10-28
  • Contact: Hu Xiao, Ph.D., 847247374@qq.com.
  • Supported by:

    This study was supported by a grant from the Development of Medical Science and Technology Project of Shandong Province in China, No. 2014WS0354; the National Natural Science Foundation of China, No. 81272099; the Shandong Medical and Health Science and Technology Development Program Fund for Youth in China, No. 2009QZ023; and the Natural Science Foundation of Shandong Province in China, No. BS2009YY043.

摘要:

实验设计以外力牵拉方法建立背部皮肤增生性瘢痕小鼠模型,拟验证皮肤神经系统与炎症参与瘢痕增生。实验以苏木精伊红染色和免疫组化染色发现,炎症导致小鼠背部皮肤增生性瘢痕的形成,瘢痕组织中神经密度增加,而Western blot证实瘢痕组织中白细胞介素13表达也出现增加。表明炎症和皮肤神经系统参与增生性瘢痕的形成,为减少瘢痕形成及有利于神经再生提供了相关的提示。

关键词: 神经再生, 周围神经再生, 增生性瘢痕, 白细胞介素13, 伤口愈合, 神经生长因子

Abstract:

This study aimed to use a mouse model of hypertrophic scarring by mechanical loading on the dorsum of mice to determine whether the nervous system of the skin and inflammation participates in hypertrophic scarring. Results of hematoxylin-eosin and immunohistochemical staining demonstrated that inflammation contributed to the formation of a hypertrophic scar and increased the nerve density in scar tissue.Western blot assay verified that interleukin-13 expression was increased in scar tissue. These findings suggest that inflammation and the cutaneous nervous system play a role in hypertrophic scar formation.

Key words: nerve regeneration, peripheral nerve regeneration, hypertrophic scar, interleukin-13, wound healing, nerve growth factor, neural regeneration