中国神经再生研究(英文版) ›› 2016, Vol. 11 ›› Issue (6): 931-936.doi: 10.4103/1673-5374.184491

• 原著:脑损伤修复保护与再生 • 上一篇    下一篇

井穴放血联合亚低温对急性重型脑外伤的神经保护

  

  • 收稿日期:2016-03-28 出版日期:2016-06-30 发布日期:2016-06-30
  • 基金资助:

    中国国家自然科学基金项目(31200809)

Neuroprotective effects of bloodletting at Jing points combined with mild induced hypothermia in acute severe traumatic brain injury

Yue Tu1, 2, #, Xiao-mei Miao1, 2, #, Tai-long Yi1, Xu-yi Chen1, Hong-tao Sun1, Shi-xiang Cheng1, 2, *, Sai Zhang1, 2, *   

  1. 1 Tianjin Key Laboratory of Neurotrauma Repair, Institute of Traumatic Brain Injury & Neuroscience of Chinese People’s Armed Police Forces, Neurosurgery & Neurology Hospital, Affiliated Hospital of Logistics University of Chinese People’s Armed Police Forces, Tianjin, China 2 Graduate School, Tianjin University of Traditional Chinese Medicine, Tianjin, China
  • Received:2016-03-28 Online:2016-06-30 Published:2016-06-30
  • Contact: Shi-xiang Cheng, M.D. or Sai Zhang, M.D., shixiangcheng@vip.126.com or zhangsai718@vip.126.com.
  • Supported by:

    This work was supported by the National Natural Science Foundation of China, No. 31200809.

摘要:

井穴放血是中国传统医学用于治疗昏迷的手段,而亚低温也有明确的神经保护作用,但两者单独应用发挥效果的时效较长。因此我们拟将两者联合应用治疗急性重型脑外伤,希望能够满足临床需求。经联合治疗后急性重型脑外伤大鼠脑水肿、血脑屏障损伤明显减轻,神经功能及细胞坏死和炎症反应明显改善。且结果显示井穴放血2d,说明2次/d,20μL联合亚低温6h干预效果优于单纯井穴放血或亚低温治疗,井穴放血联合亚低温治疗方法对急性重型脑外伤具有明显的神经保护作用。

orcid: 0000-0003-2529-719X (Shi-xiang Cheng) 0000-0002-8028-4183 (Sai Zhang)

关键词: 神经再生, 井穴, 放血, 亚低温, 急性重型脑外伤, 脑水肿, 脑水含量, 血脑屏障

Abstract:

Bloodletting at Jing points has been used to treat coma in traditional Chinese medicine. Mild induced hypothermia has also been shown to have neuroprotective effects. However, the therapeutic effects of bloodletting at Jing points and mild induced hypothermia alone are limited. Therefore, we investigated whether combined treatment might have clinical effectiveness for the treatment of acute severe traumatic brain injury. Using a rat model of traumatic brain injury, combined treatment substantially alleviated cerebral edema and bloodbrain barrier dysfunction. Furthermore, neurological function was ameliorated, and cellular necrosis and the inflammatory response were lessened. These findings suggest that the combined effects of bloodletting at Jing points (20 μL, twice a day, for 2 days) and mild induced hypothermia (6 hours) are better than their individual effects alone. Their combined application may have marked neuroprotective effects in the clinical treatment of acute severe traumatic brain injury.

Key words: nerve regeneration, Jing points, bloodletting, mild induced hypothermia, acute severe traumatic brain injury, brain edema, brain water content, blood-brain barrier, neural regeneration