中国神经再生研究(英文版)

中国神经再生研究(英文版) ›› 2014, Vol. 9 ›› Issue (14): 1365-1370.doi: 10.4103/1673-5374.137589

• 29.Traditional Chinese Medicine :nerve repair，regeneration following peripheral nerve injury • 上一篇    下一篇

电针可有效减轻臂丛神经损伤后的神经性疼痛

  

  • 收稿日期:2014-04-14 出版日期:2014-07-25 发布日期:2014-07-25
  • 基金资助:

    上海市周围神经显微外科重点实验室项目(13D22270800)，复旦大学上海医学院青年创新基金(11L-24)

Electroacupuncture attenuates neuropathic pain after brachial plexus injury

Shenyu Zhang 1, Hailiang Tang 2, Junming Zhou 1, Yudong Gu 1   

  1. 1 Department of Hand Surgery, Huashan Hospital, Fudan University; Key Laboratory of Hand Reconstruction, Ministry of Health; Shanghai Key Laboratory of Peripheral Nerve and Microsurgery, Shanghai, China
    2 Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, China
  • Received:2014-04-14 Online:2014-07-25 Published:2014-07-25
  • Contact: Junming Zhou, Department of Hand Surgery, Huashan Hospital, Fudan University; Key Laboratory of Hand Reconstruction, Ministry of Health; Shanghai Key Laboratory of Peripheral Nerve and Microsurgery, Shanghai 200040, China, zjm2585@163.com.
  • Supported by:

    This work is supported by the Project of Ministry of Health (Comprehensive Research on Brachial Plexus Injury), No. 13D22270800 from the National Natural Science Foundation of China, and 2011 Shanghai Medical College Young Scientist Fund of Fudan University, No. 11L-24.

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摘要：

电针刺激已被证实有缓解疼痛作用，但治疗臂丛神经损伤后疼痛的效果仍有待验证。实验设计了以电针刺激左侧全臂丛根性撕脱伤上肢慢性神经疼痛模型大鼠双侧曲池、合谷、足三里及阳陵泉的实验方案，发现电针治疗后，上肢慢性神经性疼痛大鼠疼痛明显减轻，且免疫荧光染色结果显示与疼痛相关的蛋白β-内啡肽在疼痛大鼠弓状核中的表达明显升高。证明电针能通过提高β-内啡肽的表达减轻臂丛神经损伤后的神经性疼痛。

关键词: 神经再生, 周围神经损伤, 臂丛神经损伤, 神经性疼痛, 电针, β-内啡肽, 慢性神经痛, 臂丛神经撕脱伤

Abstract:

Electroacupuncture has traditionally been used to treat pain, but its effect on pain following brachial plexus injury is still unknown. In this study, rat models of an avulsion injury to the left brachial plexus root (associated with upper-limb chronic neuropathic pain) were given electroacupuncture stimulation at bilateral Quchi (LI11), Hegu (LI04), Zusanli (ST36) and Yanglingquan (GB34). After electroacupuncture therapy, chronic neuropathic pain in the rats’ upper limbs was significantly attenuated. Immunofluorescence staining showed that the expression of β-endorphins in the arcuate nucleus was significantly increased after therapy. Thus, experimental findings indicate that electroacupuncture can attenuate neuropathic pain after brachial plexus injury through upregulating β-endorphin expression.

Key words: nerve regeneration, peripheral nerve injury, brachial plexus injury, neuropathic pain, electroacupuncture, β-endorphin, chronic neuropathic pain, brachial plexus avulsion, neural
regeneration