中国神经再生研究(英文版) ›› 2015, Vol. 10 ›› Issue (3): 501-504.doi: 10.4103/1673-5374.153703

• 原著:脑损伤修复保护与再生 • 上一篇    

谁在促使急性脑桥梗死患者运动功能缺损进展加速?

  

  • 收稿日期:2014-12-10 出版日期:2015-03-20 发布日期:2015-03-20

What drives progressive motor deficits in patients with acute pontine infarction?

Jue-bao Li, Rui-dong Cheng, Liang Zhou, Wan-shun Wen, Gen-ying Zhu, Liang Tian, Xiang-ming Ye   

  1. Department of Rehabilitation Medicine, Zhejiang Provincial People’s Hospital, Hangzhou, Zhejiang Province, China
  • Received:2014-12-10 Online:2015-03-20 Published:2015-03-20
  • Contact: Xiang-ming Ye, yexmdr@hotmail.com

摘要:

在急性脑桥梗死患者中进展性运动功能缺损很常见,但影响这些进展的因素尚存在许多不明了之处。以往研究已证实,急性脑桥梗死主要由基底动脉狭窄和穿支动脉疾病引起,患者会出现低位脑桥损害与进展性运动功能缺损,继发皮质脊髓束损害等较为严重的神经症状。文章综述了脑桥梗死后进展性运动功能缺损的发生机制,以及关注这些问题所能转化的治疗靶点。

关键词: 神经再生, 脑桥梗死, 进展性运动功能缺损, 基底动脉, 穿支动脉, 皮质脊髓束, Wallerian变性, 综述

Abstract:

Progressive motor deficits are relatively common in acute pontine infarction and frequently associated with increased functional disability. However, the factors that affect the progression of clinical motor weakness are largely unknown. Previous studies have suggested that pontine infarctions are caused mainly by basilar artery stenosis and penetrating artery disease. Recently, lower pons lesions in patients with acute pontine infarctions have been reported to be related to progressive motor deficits, and ensuing that damage to the corticospinal tracts may be responsible for the worsening of neurological symptoms. Here, we review studies on motor weakness progression in pontine infarction and discuss the mechanisms that may underlie the neurologic worsening.

Key words: nerve regeneration, pontine infarction, progressive motor deficits, basilar artery, penetrating arteryv corticospinal tract, Wallerian degeneration, review, neural regeneration