中国神经再生研究(英文版) ›› 2017, Vol. 12 ›› Issue (2): 267-275.doi: 10.4103/1673-5374.200810

• 原著:脊髓损伤修复保护与再生 • 上一篇    下一篇

丹参酮IIA促进脊髓损伤后下尿路功能障碍的功能恢复

  

  • 收稿日期:2016-12-29 出版日期:2017-02-15 发布日期:2017-02-15
  • 基金资助:


    中国博士后科研基金项目(2015M581120)

Tanshinone IIA improves functional recovery in spinal cord injury-induced lower urinary tract dysfunction

Yong-dong Yang1, 2, Xing Yu1, Xiu-mei Wang2, Xiao-hong Mu1, Feng He1   

  1. 1 Department of Orthopedics, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China;
    2 School of Materials Science and Engineering, Tsinghua University, Beijing, China
  • Received:2016-12-29 Online:2017-02-15 Published:2017-02-15
  • Contact: Xing Yu, M.D. or Xiu-mei Wang, Ph.D., yuxing34@sina.com or wxm@mail.tsinghua.edu.cn.
  • Supported by:

    This work was supported by the China Postdoctoral Science Foundation, No. 2015M581120.

摘要:

研究显示从中药丹参中提取的丹参酮IIA,可通过抗炎、抗氧化和抗凋亡作用,发挥神经保护功能。实验设计在大鼠脊髓损伤后连续7d静脉注射20 mg/kg丹参酮IIA。结果证明,丹参酮IIA可以减少脊髓损伤大鼠膀胱组织的炎症、水肿和代偿性增厚现象,恢复尿动力学参数,减轻继发性损伤,促进脊髓再生,同时抑制L6-S1背根神经节细胞肥大和凋亡,且效果与静脉注射30 mg/kg甲泼尼龙接近。表明丹参酮IIA可能通过参与下尿路控制的脊髓通路重构,促进脊髓损伤后下尿路功能的恢复。

ORCID:0000-0002-7836-8716(Xing Yu)

关键词: 神经再生, 脊髓损伤, 丹参酮IIA , 脊髓通路, 下尿路功能障碍, 神经源性膀胱, 背根神经节, 逼尿肌括约肌协同失调, 尿动力学

Abstract:

Tanshinone IIA, extracted from Salvia miltiorrhiza Bunge, exerts neuroprotective effects through its anti-inflammatory, anti-oxidative and anti-apoptotic properties. This study intravenously injected tanshinone IIA 20 mg/kg into rat models of spinal cord injury for 7 consecutive days. Results showed that tanshinone IIA could reduce the inflammation, edema as well as compensatory thickening of the bladder tissue, improve urodynamic parameters, attenuate secondary injury, and promote spinal cord regeneration. The number of hypertrophic and apoptotic dorsal root ganglion (L6–S1) cells was less after treatment with tanshinone IIA. The effects of tanshinone IIA were similar to intravenous injection of 30 mg/kg methylprednisolone. These findings suggested that tanshinone IIA improved functional recovery after spinal cord injury-induced lower urinary tract dysfunction by remodeling the spinal pathway involved in lower urinary tract control.

Key words: nerve regeneration, spinal cord injury, tanshinone IIA, spinal pathway, lower urinary tract dysfunction, neurogenic bladder, dorsal root ganglion, detrusor-sphincter dyssynergia, urodynamics, neural regeneration