中国神经再生研究(英文版)

中国神经再生研究(英文版) ›› 2018, Vol. 13 ›› Issue (3): 528-535.doi: 10.4103/1673-5374.228758

• 原著:脊髓损伤修复保护与再生 • 上一篇    下一篇

放射性125I粒子植入诱发兔脊髓放射性损伤的DTI及病理学变化

  

  • 收稿日期:2017-10-23 出版日期:2018-03-15 发布日期:2018-03-15
  • 基金资助:

     吉林省科技发展项目（20120724）

DTI and pathological changes in a rabbit model of radiation injury to the spinal cord after 125I radioactive seed implantation

Xia Cao1, Le Fang2, Chuan-yu Cui3, Shi Gao4, Tian-wei Wang5   

  1. 1 School of Pharmaceutical Sciences, Jilin University, Changchun, Jilin Province, China
    2 First Department of Neurology, China-Japan Union Hospital of Jilin University, Changchun, Jilin Province, China
    3 Department of MRI, Fourth Hospital, Jilin University, Changchun, Jilin Province, China
    4 Department of Nuclear Medicine, China-Japan Union Hospital of Jilin University, Changchun, Jilin Province, China
    5 Department of Radiology, China-Japan Union Hospital of Jilin University, Changchun, Jilin Province, China
  • Received:2017-10-23 Online:2018-03-15 Published:2018-03-15
  • Contact: Tian-wei Wang, Ph.D.,wtw567@sina.com.
  • Supported by:

    This study was supported by the Science and Technology Development Project Funds of Science and Technology Department of Jilin Province in China, No. 20120724.

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摘要：

过度放射性暴露可能导致脊髓组织水肿和神经系统损伤恶化，通过磁共振可以判断和评估水肿的程度评价病理变化，因而可能用于放射性治疗所致脊髓放射性损伤的评价。实验将90%靶区内体积接受的照射剂量40-100 Gy的放射性125I粒子植入兔T10椎板附近造成脊髓放射性损伤，观察其对脊髓的安全性。磁共振弥散张量成像结果见随着90%靶区内体积接受的照射剂量的增加，兔脊髓表观扩散系数和分数各向异性随着增加；且脊髓灰质和白质内的神经元及微血管的病理损伤程度，也随植入时间和90%靶区内体积接受的照射剂量的增加而加重。在植入2个月后接受各剂量照射的兔脊髓中均可见明显的病理损伤。磁共振弥散张量成像准确描述了脊髓的放射损伤，且表观扩散系数和分数各向异性可能量化脊髓损伤的程度。

orcid:0000-0002-2187-7691(Tian-wei Wang)

 

关键词: 神经再生, 近距离放射治疗, 125I放射性粒子, MRI, 脊髓放射性损伤, 弥散张量成像, 表观扩散系数, 分数各向异性

Abstract:

Excessive radiation exposure may lead to edema of the spinal cord and deterioration of the nervous system. Magnetic resonance imaging can be used to judge and assess the extent of edema and to evaluate pathological changes and thus may be used for the evaluation of spinal cord injuries caused by radiation therapy. Radioactive 125I seeds to irradiate 90% of the spinal cord tissue at doses of 40–100 Gy (D90) were implanted in rabbits at T10 to induce radiation injury, and we evaluated their safety for use in the spinal cord. Diffusion tensor imaging showed that with increased D90, the apparent diffusion coefficient and fractional anisotropy values were increased. Moreover, pathological damage of neurons and microvessels in the gray matter and white matter was aggravated. At 2 months after implantation, obvious pathological injury was visible in the spinal cords of each group. Magnetic resonance diffusion tensor imaging revealed the radiation injury to the spinal cord, and we quantified the degree of spinal cord injury through apparent diffusion coefficient and fractional anisotropy.

Key words: nerve regeneration, brachytherapy, 125I radioactive seeds, magnetic resonance imaging, radiation injury of the spinal cord, diffusion tensor imaging, apparent diffusion coefficient, fractional anisotropy, neural regeneration