中国神经再生研究(英文版) ›› 2026, Vol. 21 ›› Issue (6): 2440-2447.doi: 10.4103/NRR.NRR-D-24-00448

• 原著:脑损伤修复保护与再生 • 上一篇    下一篇

转棒训练调节少突胶质细胞系细胞逆转皮质酮诱导的运动障碍

  

  • 出版日期:2026-06-15 发布日期:2026-04-17

Rotarod training reverses corticosterone-induced motor deficits via oligodendrocyte lineage cell modulation

Jada Chia-Di Lee1, Benson Wui-Man Lau2, Suk-Yu Yau2, Joseph Wai-Hin Leung2, Harmony Kai-Hei Wong3, Dalinda Isabel Sanchez Vidana2, Tatia M.C. Lee3, 4, 5, Wu-Tian Wu1, 6, Kwok-Fai So3, 6, 7, *   

  1. 1School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, China; 
    2Department of Rehabilitation Sciences, Faculty of Health and Social Sciences, The Hong Kong Polytechnic University, Hong Kong Special Administrative Region, China; 
    3The State Key Laboratory of Brain and Cognitive Sciences, The University of Hong Kong, Hong Kong Special Administrative Region, China; 
    4Laboratory of Neuropsychology, The University of Hong Kong, Hong Kong Special Administrative Region, China; 
    5Laboratory of Cognitive Affective Neuroscience, The University of Hong Kong, Hong Kong Special Administrative Region, China; 
    6Guandong-Hong Kong-Macau Institute of CNS Regeneration (GHMICR), Jinan University, Guangzhou, Guangdong Province, China; 
    7Department of Ophthalmology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, China
  • Online:2026-06-15 Published:2026-04-17
  • Contact: Kwok-Fai So, PhD, hrmaskf@hku.hk.
  • Supported by:
    This work was supported by Hong Kong Health and Medical Research Fund, No. 02133206 (to KFS).

摘要:

啮齿类动物的大脑中不断产生成人少突胶质细胞。这些细胞的功能作用与健康动物的运动相关活动有关,对获得新的运动技能至关重要。然而,这些细胞与运动相关活动控制之间的关系尚未在病理情况下得到研究。因此,实验旨在探讨少突胶质细胞在抑郁症相关运动障碍中的作用和训练效果。在皮质酮诱导的应激范式中,成年少突胶质细胞的增殖和活化发生了改变,这与在啮齿动物运动表现中观察到的损伤一致。治疗性旋转训练可通过逆转上述变化来缓解这些症状。值得注意的是,这些改变在运动皮层 I 层尤为明显。因此,实验提供的证据表明,成年少突胶质细胞可能在功能上参与了抑郁动物的运动障碍。此外,它还为进一步研究运动皮层 I 层与这些病理状况的关系提供了初步结果。


https://orcid.org/0000-0003-4039-4246 (Kwok-Fai So)

关键词: 皮质酮诱导的应激, 运动, 重度抑郁障碍, 运动皮层, 运动障碍, 运动训练, 髓鞘化, 少突胶质细胞系细胞, 少突胶质前体细胞, 精神运动迟滞

Abstract: Adult-born oligodendrocytes are continuously produced in the brains of rodents. The functional role of these cells has been linked to the motor-related activities of healthy animals and is vital for acquiring new motor skills. However, the relationship between these cells and the control of motor-related activities has not been investigated in pathological conditions. Therefore, the aim of this study is to investigate the role of oligodendrocytes in depression-related motor deficits and the effects of training. Psychomotor retardation is a key symptom of depression. Consistent with the impairments observed in rodent motor performance, the proliferation and activation of adult-born oligodendrocytes are altered in a corticosterone-induced stress paradigm. Therapeutic rotarod training can alleviate these symptoms by reversing the aforementioned changes. Notably, these alterations are particularly pronounced in layer I of the motor cortex. Thus, this study provides evidence of the potential functional involvement of adult-born oligodendrocytes in the motor impairments observed in the depressed animals. Additionally, it offers preliminary results for further investigation into layer I of the motor cortex in relation to these pathological conditions.

Key words: corticosterone-induced stress, exercise, major depressive disorder, motor cortex, motor deficits, motor training, myelination, oligodendrocyte lineage cells, oligodendrocyte precursor cells, psychomotor retardation