中国神经再生研究(英文版)

中国神经再生研究(英文版) ›› 2026, Vol. 21 ›› Issue (10): 5071-5080.doi: 10.4103/NRR.NRR-D-25-00772

• 原著:视神经损伤修复保护与再生 • 上一篇    

视网膜保护剂枸杞多糖：基于视网膜病变啮齿动物模型临床前证据的Meta分析

  

  • 出版日期:2026-10-15 发布日期:2026-06-15

Lycium barbarum polysaccharide as a retinoprotective agent: A meta-analysis of preclinical evidence from rodent models of retinopathy

Li Jiang1, #, Erjin Wang1, #, Shengpeng Wang1, 2, *, Yitao Wang1, 2, *   

  1. 1State Key Laboratory of Mechanism and Quality Research of Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao Special Administrative Region, China;  2Macao Center for Research and Development in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao Special Administrative Region, China
  • Online:2026-10-15 Published:2026-06-15
  • Contact: Shengpeng Wang, PhD, swang@um.edu.mo; Yitao Wang, ytwang@um.edu.mo.
  • Supported by:
    This work was supported by the Science and Technology Development Fund, Macao Special Administrative Region (to YW).

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摘要：

枸杞多糖被视为枸杞的主要活性成分，其对视网膜疾病的治疗效果已有大量文献记载，但此前尚未开展系统性文献综述与荟萃分析。文章旨在通过系统回顾已发表的动物实验，对枸杞多糖在啮齿类视网膜疾病模型中发挥抗氧化、抗炎、抗凋亡及神经保护作用的机制进行荟萃分析。为客观定量比较枸杞多糖在啮齿类视网膜疾病模型中的疗效，此系统综述检索PubMed及Web of Science数据库 (建库至2024年7月)，筛选符合预设纳入标准的动物研究。最终纳入研究27项报告了视网膜结构(外核层厚度)或功能(视网膜电图b波振幅)的结局指标。采用SYRCLE偏倚风险评估工具评估方法学质量显示，纳入文献总体偏倚风险以中等偏倚为主。使用RevMan 5.4.1软件进行Meta分析结果发现，荧光素明暗视力表 (枸杞多糖)通过增加外核层厚度和b波振幅，在动物模型中被证实具有保护视网膜免受损伤的作用，其作用机制包括抗氧化、抗炎、抗凋亡以及调节胶质细胞驱动的神经炎症。文章结果证实了对视网膜外核层厚度及神经细胞的保护机制，并为枸杞多糖的转化研究提出未来策略。


https://orcid.org/0000-0003-3575-9212 (Shengpeng Wang); https://orcid.org/0000-0003-4355-6490 (Yitao Wang)

关键词: 抗氧化剂, 细胞凋亡, 实验动物模型, 枸杞, 荟萃分析, 神经炎症, 神经保护, 多糖, 视网膜疾病, Meta分析, 胶质细胞

Abstract: Lycium barbarum polysaccharides are considered the primary active ingredient of Lycium barbarum, and their therapeutic effects on retinal diseases have been extensively described. However, a systematic review and meta-analysis of these studies have not been conducted previously. This review aims to systematically review and meta-analyze published animal studies to investigate the mechanisms of the antioxidative, anti-inflammatory, anti-apoptotic, and neuroprotective effects of Lycium barbarum polysaccharides in rodent models of retinal diseases. To objectively and quantitatively compare the efficacy of Lycium barbarum polysaccharides in rodent models of retinal disease, a systematic review was conducted to search the PubMed and Web of Science databases (from inception to July 2024) for studies conducted in animals that met all a priori inclusion criteria. The included 27 studies reported outcomes on retinal structure (outer nuclear layer thickness) or function (electroretinogram b-wave amplitude). The methodological quality, assessed using the SYRCLE bias risk assessment tool, indicated that the overall risk of bias in the included literature was predominantly moderate. The results of the meta-analysis conducted using RevMan 5.4.1 software found that Lycium barbarum polysaccharides are protective against retinal injury in animal models, as evidenced by increases in the thickness of the outer nuclear layer and b-wave amplitude. The mechanisms involved include antioxidant effects, anti-inflammation, anti-apoptosis, and modulation of glia-driven neuroinflammation. Findings from this review confirm the protective actions of Lycium barbarum polysaccharides on retinal outer nuclear layer thickness and neuronal cells in rodent models of retinal diseases and may help propose strategies for future translational research on Lycium barbarum polysaccharides. 

Key words: antioxidant, apoptosis, experimental animal models, Lycium, meta-analysis, neuroinflammation, neuroprotection, polysaccharide, retinal diseases