中国神经再生研究(英文版)

中国神经再生研究(英文版) ›› 2018, Vol. 13 ›› Issue (10): 1787-1795.doi: 10.4103/1673-5374.238623

• 原著:脑损伤修复保护与再生 • 上一篇    下一篇

阈值技术分析脊髓损伤患者大腿共振图像半自动分割区室

  

  • 收稿日期:2018-07-12 出版日期:2018-10-15 发布日期:2018-10-15
  • 基金资助:

    这项研究得到退伍军人事务部，退伍军人健康管理局，康复研究和开发服务（B7867-W）部和DoD-CDRMP（W81XWH-14-SCIRP-CTA）资助

Semi-automated segmentation of magnetic resonance images for thigh skeletal muscle and fat using threshold technique after spinal cord injury

Mina P. Ghatas1, Robert M. Lester1, M. Rehan Khan2, Ashraf S. Gorgey1, 3   

  1. 1 Department of Spinal Cord Injury and Disorders, Hunter Holmes McGuire VA Medical Center, Richmond, VA, USA
    2 Department of Radiology, Hunter Holmes McGuire VA Medical Center, Richmond, VA, USA
    3 Department of Physical Medicine and Rehabilitation, Virginia Commonwealth University, Richmond, VA, USA
  • Received:2018-07-12 Online:2018-10-15 Published:2018-10-15
  • Contact: Ashraf S. Gorgey, MPT, PhD,FACSM, ashraf.gorgey@va.gov.
  • Supported by:

    This study was supported by the Department of Veteran Affairs, Veteran Health Administration, Rehabilitation Research and Development Service (B7867-W) and DoD-CDRMP (W81XWH-14-SCIRP-CTA) (to ASG).

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摘要：

MRI被认为是量化大腿肌肉和脂肪横截面积（CSA）的“金标准”技术。我们开发了一种半自动化技术，用于分割脊髓损伤（SCI）患者的7个大腿区室。使用以盲法分析来自18例完全性脊髓损伤的男性患者（18-50岁）的大腿MRI图像，比较通过阈值处理与手动跟踪技术获得的CSA值。结果显示：（1）大腿围的百分比误差为0.74％（阈值：170.71±38.67;手动：169.45±38.27 cm2）；（2）皮下脂肪组织为5.2％（阈值：65.99±30.79;手动：62.68±30.22）；（3）全肌为0.13％（阈值：98.18±20.19;手动：98.20±20.08 cm2）；（4）股骨为0.64％（阈值：6.53±1.09;手动：6.53±1.09 cm2）；（5）骨髓脂肪为0.36％（阈值：3.12±1.12;手册：3.1±1.11 cm2）；（6）膝伸肌为1.78％（阈值：43.98±7.66;手动：44.61±7.81 cm2）；（7）％肌肉内脂肪为0.47％（阈值：10.45±4.29;手动：10.92±8.35％）。（8）这些结果表明，阈值技术在磁共振图像半自动分割法测量7个主要大腿隔室时提供了稳健的准确性，同时大大缩短了分析时间。

orcid:0000-0002-9157-6034(Ashraf S. Gorgey)

 

关键词: 脊髓损伤, 磁共振成像, 半自动分割, 皮下脂肪组织, 肌内脂肪, 神经再生

Abstract:

Magnetic resonance imaging is considered the “gold standard” technique for quantifying thigh muscle and fat cross-sectional area. We have developed a semi-automated technique to segment seven thigh compartments in persons with spinal cord injury. Thigh magnetic resonance images from 18 men (18–50 years old) with traumatic motor-complete spinal cord injury were analyzed in a blinded fashion using the threshold technique. The cross-sectional area values acquired by thresholding were compared to the manual tracing technique. The percentage errors for thigh circumference were (threshold: 170.71 ± 38.67; manual: 169.45 ± 38.27 cm2) 0.74%, subcutaneous adipose tissue (threshold: 65.99±30.79; manual: 62.68 ± 30.22) 5.2%, whole muscle (threshold: 98.18 ± 20.19; manual: 98.20 ± 20.08 cm2) 0.13%, femoral bone (threshold: 6.53 ± 1.09;manual: 6.53 ± 1.09 cm2) 0.64%, bone marrow fat (threshold: 3.12 ± 1.12; manual: 3.1 ± 1.11 cm2) 0.36%,knee extensor (threshold: 43.98 ± 7.66; manual: 44.61 ± 7.81 cm2) 1.78% and % intramuscular fat (threshold: 10.45 ± 4.29; manual: 10.92 ± 8.35%) 0.47%. Collectively, these results suggest that the threshold technique provided a robust accuracy in measuring the seven main thigh compartments, while greatly reducing the analysis time.

Key words: spinal cord injury, magnetic resonance imaging, semi-automated segmentation, subcutaneous adipose tissue, intramuscular fat