中国神经再生研究(英文版)

中国神经再生研究(英文版) ›› 2022, Vol. 17 ›› Issue (5): 1059-1064.doi: 10.4103/1673-5374.324849

• 原著:脊髓损伤修复保护与再生 • 上一篇    下一篇

针刺对轻中度酒精成瘾引起大脑激活的影响

  

  • 出版日期:2022-05-15 发布日期:2021-11-22

Effects of acupuncture stimulation on brain activation induced by cue-elicited alcohol craving

Hyeok Gyu Kwon1, Seong Hun Choi2, Joon Ho Seo3, Chae Ha Yang4, *, Mi Young Lee5, *   

  1. 1Department of Physical Therapy, College of Health Science, Eulji University, Gyeonggi, Republic of Korea; 2Department of Anatomy and Histology, College of Oriental Medicine, Daegu Haany University, Gyeongsan, Republic of Korea; 3Department of Rehabilitation, Gyeongbuk Regional Rehabilitation Hospital, Gyeongsan, Republic of Korea; 4Department of Physiology, College of Korean Medicine, Daegu Haany University, Daegu, Republic of Korea; 5Department of Physical Therapy, College of Biomedical Science, Daegu Haany University, Gyeongsan, Republic of Korea
  • Online:2022-05-15 Published:2021-11-22
  • Contact: Chae Ha Yang, PhD, chyang@dhu.ac.kr; Mi Young Lee, PhD, mykawai@hanmail.net.
  • Supported by:
    This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIT), No. 2018R1A5A2025272 (to CHY and MYL).

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摘要： 研究已证实，针刺对酒精成瘾的治疗有一定效果，但其机制尚待进一步研究。为了解针刺神门（HT7）穴对酒精成瘾引起的大脑激活的影响，此项随机对照研究从社区招募了30名轻中度饮酒的右利手健康志愿者，按1：1比例，随机给予受试者针刺HT7（实验穴位）和经渠（LU8，对照穴位）干预。研究在大邱Haany大学和DGMIF（大邱-庆北医学创新基金会）于2018年12月至2019年5月完成。结果显示，针刺HT7后，受试者眶额叶皮质（OFC）和背外侧前额叶皮质（DLPFC）激活明显增加，而尾状核的激活明显减少，从而削弱了受试者在观看与酒精有关的视频片段，如各种酒精（啤酒、葡萄酒或烧酒）或饮酒场景时，对酒精的渴求。针刺HT7 明显较针刺LU8更能减轻受试者对酒精的依赖。这些结果表明，针刺可以通过激活眶额叶皮质和背外侧前额叶皮质，来改善轻中度酒精成瘾者自我控制，从而减轻对酒精的渴求。

Abstract: Acupuncture has been shown to be effective on alcohol use disorder. However, the underlying mechanism remains poorly understood. To investigate the effects of Shenmen (HT7) acupoint on brain activation induced by cue-elicited alcohol craving, 30 right-handed healthy light to moderate alcohol drinkers were recruited from the community. They were randomly assigned to undergo acupuncture either at HT7 (experimental acupoint, n = 15) or Jingqu (LU8, control acupoint, n = 15) acupoints. This randomized controlled study was performed in Daegu Haany University and Daegu-Gyeongbuk Medical Innovation Foundation, Republic of Korea. Recruitment and data collection were conducted from December 2018 to May 2019. The results showed that after acupuncture at HT7 acupoint, the activation of orbitofrontal cortex and dorsolateral prefrontal cortex was greatly increased, while the activation of dorsolateral prefrontal cortex was obviously reduced, and subject’s craving for alcohol was reduced when he/she seeing alcohol-related video clips involving various alcohols (beer, wine, or soju) or drinking scenarios. Acupuncture at HT7 more greatly reduced subject’s alcohol cravings than acupuncture at LU8 acupoint. These findings suggest that acupuncture can improve the self-control of mild to moderate social drinkers through the activation of the orbitofrontal cortex and dorsolateral prefrontal cortex, thereby reducing the craving for alcohol. The study protocol was approved by the Institutional Review Board of Daegu Haany University Korean Medicine Hospital, Republic of Korea (approval No. DHUMC-D-18026-PRO-02) on November 30, 2018.

Key words: acupuncture, addiction, alcohol, brain activation, craving, cue, functional MRI, Shenmen (HT7) acupoint

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