中国神经再生研究(英文版)

中国神经再生研究(英文版) ›› 2013, Vol. 8 ›› Issue (24): 2275-2283.doi: 10.3969/j.issn.1673-5374.2013.24.007

• 综述:退行性病与再生 • 上一篇    下一篇

自噬与神经退行性疾病

  

  • 收稿日期:2013-03-15 修回日期:2013-06-25 出版日期:2013-08-25 发布日期:2013-08-25

Autophagy and neurodegenerative disorders

Evangelia Kesidou1, Roza Lagoudaki1, Olga Touloumi1, Kyriaki-Nefeli Poulatsidou1, Constantina Simeonidou2   

  1. 1 Laboratory of Experimental Neurology and Neuroimmunology, Second Department of Neurology, AHEPA University Hospital, Aristotle University of Thessaloniki, Macedonia, Greece
    2 Department of Experimental Physiology, Medical School, Aristotle University of Thessaloniki, Macedonia, Greece
  • Received:2013-03-15 Revised:2013-06-25 Online:2013-08-25 Published:2013-08-25
  • Contact: Constantina Simeonidou, M.D., Ph.D., Associate professor of physiology, Department of Experimental Physiology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Macedonia, Greece, symeon@med.auth.gr.
  • About author:Evangelia Kesidou, M.Sc., Biologist.

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摘要：

变异蛋白和包涵体积聚是大多数神经退行性疾病的标志，在神经元内这些物质的积聚会产生神经毒性，促使活性氧簇过度产生，诱发氧化应激。自噬是机体清除过量、老化蛋白质及受损细胞器，维持细胞内环境稳定的重要途径。神经元中自噬过度和不足均可使其内环境发生改变，从而影响神经元的存活，产生神经退行性疾病。我们认真收集和分析了相关研究内容，综述了自噬在典型的慢性和急性神经退行性疾病中的作用或相关性。

关键词: 神经再生, 综述, 神经退行性疾病, 氧化应激, 自噬, ATG基因, 凋亡, 帕金森病, 肌萎缩侧索硬化, 多发性硬化

Abstract:

Accumulation of aberrant proteins and inclusion bodies are hallmarks in most neurodegenerative diseases. Consequently, these aggregates within neurons lead to toxic effects, overproduction of reactive oxygen species and oxidative stress. Autophagy is a significant intracellular mechanism that removes damaged organelles and misfolded proteins in order to maintain cell homeostasis. Excessive or insufficient autophagic activity in neurons leads to altered homeostasis and influences their survival rate, causing neurodegeneration. The review article provides an update of the role of autophagic process in representative chronic and acute neurodegenerative disorders.

Key words: neural regeneration, reviews, oxidative stress, autophagy, autophagy-related genes, apoptosis, Parkinson’s disease, amyotrophic lateral sclerosis, multiple sclerosis, acute and chronic neurodegeneration, neuroregeneration