中国神经再生研究(英文版)

中国神经再生研究(英文版) ›› 2013, Vol. 8 ›› Issue (26): 2424-2431.doi: 10.3969/j.issn.1673-5374.2013.26.003

• 原著:神经损伤修复保护与再生 • 上一篇    下一篇

功能MRI研究揭示学习任务指向对源记忆的影响

  

  • 收稿日期:2013-04-20 修回日期:2013-06-10 出版日期:2013-09-15 发布日期:2013-09-15
  • 基金资助:

    自然科学基金（31100728，90924013，31271090）；上海哲学社科“十二五”规划课题教育学专项（2012JJY001）；复旦大学“985工程”三期整体推进社会学科研究项目（2011SHKXZD008）

Effects of task orientation on subsequent source memory as revealed by functional MRI

Xiuyan Guo1, 2, Lei Zhu3, Li Zheng2, Jianqi Li1, 4, Qianfeng Wang1, 4, Zhiliang Yang2   

  1. 1 Shanghai Key Laboratory of Magnetic Resonance, East China Normal University, Shanghai 200062, China

    2 School of Psychology and Cognitive Science, East China Normal University, Shanghai 200062, China

    3 Department of Psychology, Fudan University, Shanghai 200433, China

    4 Department of Physics, East China Normal University, Shanghai, 200062, China
  • Received:2013-04-20 Revised:2013-06-10 Online:2013-09-15 Published:2013-09-15
  • Contact: Lei Zhu, Ph.D., Associate professor, Department of Psychology, Fudan University, Shanghai 200433, China, judy1981_81@hotmail.com.
  • About author:Lei Zhu, Ph.D., Associate professor, Department of Psychology, Fudan University, Shanghai 200433, China, judy1981_81@hotmail.com.

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摘要：

源记忆是情节记忆的一个重要方面，其中，最令研究者感兴趣的问题为：是什么决定了人们能否记住识记项目的来源信息？行为研究发现，学习任务的指向性会影响源记忆的成绩。实验通过功能MRI扫描受试者在学习阶段完成项目指向任务和来源指向任务时海马和前额叶脑区的变化，并以测试阶段受试者的判断结果作为依据，探讨学习任务的指向影响源记忆的神经机制。结果发现，右侧前额叶和海马的源记忆效应受到任务指向的影响，而前额叶的项目记忆效应则会受任务指向的影响。这说明海马的功能在于有意识编码项目和来源信息之间的联系，即来源记忆，而前额叶的功能则倾向于加工那些被注意到的信息。

关键词: 神经再生, 神经影像, 神经心理, 学习, 源记忆, 任务指向, 神经机制, 海马, 前额叶, 功能MRI, 基金资助文章

Abstract:

Episodic memories are composed of various interrelated elements, including those specific to items of central interest and those pertaining to related features, such as the color, shape, size, spatial location, temporal order, and media or modalities of presentation. Memory about a core item (such as a word, object, or picture) is called item memory while memory about the context or related fea-tures of a core item is defined as source memory. What determines which sources within an episode are successfully remembered is of particular interest to researchers. Behavioral evidence suggests that the orientation of a memory task influences whether the related source of the item will be re-membered later. This study explored changes in the hippocampus and prefrontal cortex while par-ticipants completed two tasks: an item-oriented task and a source-oriented task. We used functional MRI to investigate the neural mechanisms by which task orientation influences source encoding. We found that subsequent source memory effects in the right prefrontal cortex and hippocampus were modulated by task orientation, whereas task orientation modulated item memory effects in the prefrontal cortex. These findings highlight the possibility that the hippocampus contributes to the intentional encoding of item-source associations, whereas the prefrontal cortex is biased toward processing information to which attention is directed.

Key words: neural regeneration, neuropsychology, learning, source memory, task orientation, hippocampus, prefrontal cortex, functional MRI, grants-supported paper, neuroregeneration