中国神经再生研究(英文版)

中国神经再生研究(英文版) ›› 2013, Vol. 8 ›› Issue (30): 2849-2855.doi: 10.3969/j.issn.1673-5374.2013.30.007

• 原著:脊髓损伤修复保护与再生 • 上一篇    下一篇

嗅鞘细胞移植改善晚期脊髓损伤患者运动、感觉及交感神经皮肤反应

  

  • 收稿日期:2013-06-19 修回日期:2013-06-19 出版日期:2013-10-25 发布日期:2013-10-25

Olfactory ensheathing cell transplantation improves sympathetic skin responses in chronic spinal cord injury

Zuncheng Zheng1, Guifeng Liu1, Yuexia Chen1, Shugang Wei2   

  1. 1 Department of Orthopedics, Taian Central Hospital, Taian 271000, Shandong Province, China
    2 Department of Spine and Spinal Cord, Taian Rongjun Hospital, Taian 271000, Shandong Province, China
  • Received:2013-06-19 Revised:2013-06-19 Online:2013-10-25 Published:2013-10-25
  • Contact: Zuncheng Zheng, Master, Associate chief physician, Associate professor, Department of Orthopedics, Shandong Central Hospital, Taian 271000, Shandong Province, China, zhengzc1965@126.com.

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摘要：

手术显微镜下对43例病程大于6个月的晚期脊髓损伤患者行脊髓损伤区域多靶点胚胎嗅鞘细胞移植，移植细胞数为（2～4）×106个。分别于移植前1 d和移植后3周~2个月应用肌电图诱发电位仪检测患者交感神经皮肤反应，采用美国脊髓损伤学会量表评估患者的脊髓神经功能。结果显示43例患者嗅鞘细胞移植前交感神经皮肤反应引出32例，移植后引出34例；同时，与移植前比较，移植后患者交感神经皮肤反应潜伏期明显缩短，波幅明显增高。嗅鞘细胞移植后患者美国脊髓损伤学会运动、痛觉、触觉评分也较移植前有所提高。提示嗅鞘细胞损伤局部移植能改善晚期脊髓损伤患者运动、感觉及植物神经功能。

关键词: 神经再生, 脊髓损伤, 临床实践, 嗅鞘细胞, 细胞移植, 嗅鞘细胞移植, 交感神经皮肤反应, 神经功能, 植物神经, 瘫痪

Abstract:

Forty-three patients with chronic spinal cord injury for over 6 months were transplanted with em-bryonic olfactory ensheathing cells, 2–4 × 106, into multiple sites in the injured area under the sur-gical microscope. The sympathetic skin response in patients was measured with an electromyog-raphy/evoked potential instrument 1 day before transplantation and 3–8 weeks after transplantation. Spinal nerve function of patients was assessed using the American Spinal Injury Association im-pairment scale. The sympathetic skin response was elicited in 32 cases before olfactory ensheathing cell transplantation, while it was observed in 34 cases after transplantation. Concomi-tantly, sympathetic skin response latency decreased significantly and amplitude increased signifi-cantly after transplantation. Transplantation of olfactory ensheathing cells also improved American Spinal Injury Association scores for movement, pain and light touch. Our findings indicate that ol-factory ensheathing cell transplantation improves motor, sensory and autonomic nerve functions in patients with chronic spinal cord injury.

Key words: neural regeneration, spinal cord injury, clinical practice, olfactory ensheathing cells, cell transplan-tation, olfactory ensheathing cell transplantation, sympathetic skin response, neurological function, autonomic nerve, paralysis, neuroregeneration