中国神经再生研究(英文版)

中国神经再生研究(英文版) ›› 2013, Vol. 8 ›› Issue (8): 731-744.doi: 10.3969/j.issn.1673-5374.2013.08.008

• 综述:脑损伤修复保护与再生 • 上一篇    下一篇

内源性大麻素系统对缺氧缺血性脑损伤的神经保护？

  

  • 收稿日期:2012-12-11 修回日期:2013-02-07 出版日期:2013-03-15 发布日期:2013-03-15
  • 基金资助:

    西班牙卫生部健康保健基金（No. PS09/ 02326）；西班牙巴斯克政府基金（No. GCI-07/79, IT-287-07）

Using the endocannabinoid system as a neuroprotective strategy in perinatal hypoxic- ischemic brain injury

Lara-Celador, I.1, Goñi-de-Cerio, F.2, Antonia Alvarez1, Enrique Hilario1   

  1. 1 Department of Cell Biology and Histology, School of Medicine and Dentistry, University of the Basque Country, Leioa 48949, Bizkaia, Spain
    2 GAIKER Technology Centre, Bizkaia Science and Technology Park, Building 202, Zamudio 48170, Bizkaia, Spain
  • Received:2012-12-11 Revised:2013-02-07 Online:2013-03-15 Published:2013-03-15
  • Contact: Enrique Hilario, M.D., Department of Cell Biology and Histology, School of Medicine and Dentistry, University of the Basque Country, E-48940 Leioa, Vizcaya, Spain, enrique.hilario@ehu.es.
  • Supported by:

    This work was supported by grants from Funding Health Care of Spanish Ministry of Health, No. PS09/ 02326, and from the Basque Government, No. GCI-07/79, IT-287-07.

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摘要：

缺氧缺血性脑病是导致新生儿死亡的重要原因之一，其涉及的分子机制十分复杂。因此，目前缺氧缺血性脑病的治疗效果仍不十分理想。在各种神经保护治疗中，内源性大麻素系统作为天然的神经保护系统，已逐渐引起人们的重视。文章综述了缺氧缺血性脑病的病理损害，各种神经保护手段对缺氧缺血性脑病的治疗效果，重点分析了内源性大麻素系统在缺氧缺血性脑损伤防治中所起到的重要作用。

关键词: 神经再生, 综述, 围产期, 缺氧缺血, 脑损伤, 脑可塑性, 神经保护, 大麻素系统, 基金资助文章, 图片文章

Abstract:

One of the most important causes of brain injury in the neonatal period is a perinatal hypoxic- ischemic event. This devastating condition can lead to long-term neurological deficits or even death. After hypoxic-ischemic brain injury, a variety of specific cellular mechanisms are set in motion, triggering cell damage and finally producing cell death. Effective therapeutic treatments against this phenomenon are still unavailable because of complex molecular mechanisms underlying hypoxic-ischemic brain injury. After a thorough understanding of the mechanism underlying neural plasticity following hypoxic-ischemic brain injury, various neuroprotective therapies have been developed for alleviating brain injury and improving long-term outcomes. Among them, the endocannabinoid system emerges as a natural system of neuroprotection. The endocannabinoid system modulates a wide range of physiological processes in mammals and has demonstrated neuroprotective effects in different paradigms of acute brain injury, acting as a natural neuroprotectant. The aim of this review is to study the use of different therapies to induce long-term therapeutic effects after hypoxic-ischemic brain injury, and analyze the important role of the endocannabinoid system as a new neuroprotective strategy against perinatal hypoxic-ischemic brain injury.

Key words: neural regeneration, reviews, perinatal hypoxia-ischemia, brain injury, brain plasticity, neuroprotective strategies, cannabinoid system, grants-supported paper, photographs-containing paper, neuroregeneration