中国神经再生研究(英文版)

中国神经再生研究(英文版) ›› 2013, Vol. 8 ›› Issue (13): 1228-1235.doi: 10.3969/j.issn.1673-5374.2013.13.008

• 原著:脑损伤修复保护与再生 • 上一篇    下一篇

与亚洲人缺血性脑卒中相关的血管紧张素原基因多态性：meta分析

  

  • 收稿日期:2012-12-25 修回日期:2013-03-20 出版日期:2013-05-05 发布日期:2013-05-05

Angiotensinogen gene polymorphism and ischemic stroke in East Asians

Sheng Wang1, Rong Zeng2, Limin Lei2, Jinsong Huang2   

  1. 1 Department of Anesthesiology, Guangdong Cardiovascular Institute, Guangdong Academy of Medical Sciences, Guangdong General Hospital, Guangzhou 510080, Guangdong Province, China
    2 Department of Cardiovascular Surgery, Guangdong Cardiovascular Institute, Guangdong Academy of Medical Sciences, Guangdong General Hospital, Guangzhou 510080, Guangdong Province, China
  • Received:2012-12-25 Revised:2013-03-20 Online:2013-05-05 Published:2013-05-05
  • Contact: Jinsong Huang, M.D., Associate chief physician, Department of Cardiovascular Surgery, Guangdong Cardiovascular Institute, Guangdong Academy of Medical Sciences, Guangdong General Hospital, Guangzhou 510080, Guangdong Province, China, jasonwong32@hotmail.com.
  • About author:Sheng Wang☆, M.D., Associate chief physician.

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摘要：

目的：探讨亚洲人群血管紧张素原基因M235T多态性与缺血性卒中之间的联系。
资料来源：以“angiotensinogen or AGT，polymorphism or genetic，ischemic stroke or cerebral infarction”为检索词，检索PubMed，google scholar，CNKI数据库中1990-01/2012-04发表的相关文献。
资料选择：纳入血管紧张素原基因M235T多态性与缺血性卒中关系的病例-对照研究，研究对象为亚洲人群，且基因型分布符合Hardy-Weinberg遗传平衡。纳入文献由2名作者进行质量评价，经严格筛选后，采用Stata 12.0软件对纳入文献进行Meta分析，并进一步进行异质性检验、敏感性分析及偏倚评估。
结局评价指标：血管紧张素原基因M235T多态性与缺血性卒中的关联。
结果：共纳入6篇相关文献，包含891例缺血性卒中患者和727例对照人群。Meta分析结果显示血管紧张素原基因M235T多态性与缺血性卒中相关(T vs. M：OR=1.54, 95%CI：1.10-2.16；TT vs. MM：OR=2.24, 95%CI：1.37-3.66；TT vs. MT：OR=1.76，95% CI：1.41-2.20，MM+MT vs. TT：OR=0.57, 95% CI：0.46-0.70)。同时敏感性分析结果证实研究稳定可靠，未见明显发表偏倚。
结论：在亚洲人群中，血管紧张素原基因M235T多态性与缺血性卒中相关，TT基因型和T等位基因是缺血性卒中的危险因素。

关键词: 神经再生, 脑损伤, 脑血管疾病, 血管紧张素原, 缺血性卒中, 基因多态性, 危险因素, meta分析, 亚洲人群, 遗传多态性, 脑梗死

Abstract:

OBJECTIVE: To investigate the association between angiotensinogen gene M235T polymorphism and ischemic stroke in East Asians.
DATA RETRIEVAL: A computer-based online search was conducted in PubMed, Google scholar, China National Knowledge lnfrastructure database between January 1990 and April 2012 for relevant studies. The key words were angiotensinogen or AGT, polymorphism or genetic and ischemic stroke or cerebral infarction.
SELECTION CRITERIA: Case-controlled studies addressing the correlation between angiotensinogen gene M235T polymorphism and ischemic stroke in East Asians were included. The distribution of genotypes in the included studies was tested for Hardy-Weinberg equilibrium. Quality evaluation of the included studies was conducted by two physicians. Statistical analyses were carried out using Stata 12.0 software for meta-analysis. Heterogeneity tests, sensitivity analysis and publication bias were also conducted.
MAIN OUTCOME MEASURES: The association between angiotensinogen gene M235T polymorphism and ischemic stroke risk in East Asians was assessed.
RESULTS: Six relevant studies involving 891 patients with ischemic stroke and 727 controls were included in this meta-analysis. Results showed that there was a significant association between angiotensinogen gene M235T polymorphism and the risk of ischemic stroke in East Asians (T vs. M: odds ratio (OR) = 1.54, 95% confidence interval (CI) = 1.10–2.16; TT vs. MM: OR = 2.24, 95%CI = 1.37–3.66; TT vs. MT: OR = 1.76, 95%CI = 1.41–2.20; MM + MT vs. TT: OR = 0.57, 95%CI = 0.46–0.70). Sensitivity analysis confirmed that the study results were stable and reliable, with no publication bias.
CONCLUSION: The angiotensinogen gene M235T polymorphism is associated with ischemic stroke in East Asians, and the TT genotype and T allele are risk factors for ischemic stroke.

Key words: neural regeneration, brain injury, cerebrovascular disease, angiotensinogen, ischemic stroke, risk factor, meta-analysis, East Asians, genetic polymorphism, cerebral infarction, grants-supported paper, neuroregeneration