中国神经再生研究(英文版)

中国神经再生研究(英文版) ›› 2013, Vol. 8 ›› Issue (14): 1286-1296.doi: 10.3969/j.issn.1673-5374.2013.14.005

• 原著:脊髓损伤修复保护与再生 • 上一篇    下一篇

嗅鞘细胞移植治疗脊髓损伤：Web of Science数据库18年文献分析

  

  • 收稿日期:2012-12-29 修回日期:2013-02-22 出版日期:2013-05-15 发布日期:2013-05-15

Olfactory ensheathing cell transplantation for spinal cord injury

Zikuan Leng, Xijing He, Haopeng Li, Dong Wang, Kai Cao   

  1. Department of Orthopedics, the Second Affiliated Hospital, Medical School of Xi’an Jiaotong University, Xi’an 710004, Shaanxi Province, China
  • Received:2012-12-29 Revised:2013-02-22 Online:2013-05-15 Published:2013-05-15
  • Contact: Xijing He, Ph.D., M.D., Professor, Department of Orthopedics, the Second Affiliated Hospital, Medical School of Xi’an Jiaotong University, Xi’an 710004, Shaanxi Province, China, xijing_h@vip.tom.com.
  • About author:Zikuan Leng★, Master.

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摘要：

目的：嗅鞘细胞移植是治疗脊髓损伤的研究热点，相关研究文献数量逐年增加，但对这些文献的计量分析报告目前并不多。
资料来源：检索美国科学情报研究所（ISI）出版的Web of Science数据库（包括SCI-EXPANDED，SSCI，A&HCI，CPCI-S，CPCI-SSH，BKCI-S，BKCI-SSH，CCR-EXPANDED，IC）获得嗅鞘细胞移植治疗脊髓损伤领域1898-01/2012-05期间的文献。检索关键词为"olfactory ensheathing cells" or "OECs" or "olfactory ensheathing glia" or "OEG" or "olfactory ensheathing glia cells" or "OEGs" and"spinal cord injury" or "SCI" or "spinal injury" or "spinal transection"。
资料选择：纳入嗅鞘细胞移植治疗脊髓损伤研究相关的研究原著、综述、会议记录及摘要、快报文章和编辑素材，同时排除未发表文献及需要人工获取来源的文献。
结局评价指标：从出版时间分布、语种、文献类型、作者、研究机构、文献被引频次分布、Web of Science分类、出版杂志、国家/地区分布和基金资助机构等方面对嗅鞘细胞移植治疗脊髓损伤研究相关文献进行统计和计量分析。
结果：SCI数据库中关于嗅鞘细胞移植治疗脊髓损伤的最早文献记录是1995年4月出版的文章，在随后的18年里每年该研究领域的研究文献逐年增加；415篇文献中有405篇是以英文发表的；文献类型分析中研究原著以259篇排在首位，综述为141篇。其中有30篇研究原著和20篇综述，引用超过55次，可以认为是经典的文献；该研究领域内以Experimental Neurology出版32篇居首，Glia紧随其后；美国发表的文献数量全球最多，中国其次。其中耶鲁大学是全球在嗅鞘细胞移植治疗脊髓损伤领域发表文献量最多的机构，第二军医大学是中国研究嗅鞘细胞移植治疗脊髓损伤领域发表文献量最多的机构。美国作者所发表文献主要发表在Experimental Neurology，中国作者在该领域的研究文献主要发表在Neural Regeneration Research。
结论：文章较全面的分析了Web of Science数据库中嗅鞘细胞移植治疗脊髓损伤的历年文献分布状况，为该领域学者开展有针对性的技术交流和研究合作提供了有价值的参考，以利于探索更有效的脊髓损伤治疗方法。

关键词: 神经再生, 脊髓损伤, 嗅鞘细胞, 细胞移植, 脊髓横断, 组织工程, 种子细胞, Web of Science数据库, 文献计量学, 基金资助文章

Abstract:

OBJECTIVE: Olfactory ensheathing cell (OEC) transplantation is a promising new approach for the treatment of spinal cord injury (SCI), and an increasing number of scientific publications are devoted to this treatment strategy. This bibliometric analysis was conducted to assess global research trends in OEC transplantation for SCI.
DATA SOURCE: All of the data in this study originate from the Web of Science maintained by the Institute for Scientific Information, USA, and includes SCI-EXPANDED, SSCI, A&HCI, CPCI-S, CPCI-SSH, BKCI-S, BKCI-SSH, CCR-EXPANDED and IC. The Institute for Scientific Information’s Web of Science was searched using the keywords “olfactory ensheathing cells” or “OECs” or “olfactory ensheathing glia” or “OEG” or “olfactory ensheathing glial cells” or “OEGs” and “spinal cord injury” or “SCI” or “spinal injury” or “spinal transection” for literature published from January 1898 to May 2012.
DATA SELECTION: Original articles, reviews, proceedings papers and meeting abstracts, book chapters and editorial materials on OEC transplantation for SCI were included. Simultaneously, unpublished literature and literature for which manual information retrieval was required were excluded.
MAIN OUTCOME MEASURES: All selected literatures addressing OEC transplantation for SCI were evaluated in the following aspects: publication year, document type, language, author, institution, times cited, Web of Science category, core source title, countries/territories and funding agency.
RESULTS: In the Web of Science published by the Institute for Scientific Information, the earliest literature record was in April, 1995. Four hundred and fourteen publications addressing OEC transplantation for SCI were added to the data library in the past 18 years, with an annually increasing trend. Of 415 records, 405 publications were in English. Two hundred and fifty-nine articles ranked first in the distribution of document type, followed by 141 reviews. Thirty articles and 20 reviews, cited more than 55 times by the date the publication data were downloaded by us, can be regarded as the most classical references. The journal Experimental Neurology published the most literature (32 records), followed by Glia. The United States had the most literature, followed by China. In addition, Yale University was the most productive institution in the world, while The Second Military Medical University contributed the most in China. The journal Experimental Neurology published the most OEC transplantation literature in the United States, while Neural Regeneration Research published the most in China.
CONCLUSION: This analysis provides insight into the current state and trends in OEC transplantation for SCI research. Furthermore, we anticipate that this analysis will help encourage international cooperation and teamwork on OEC transplantation for SCI to facilitate the development of more effective treatments for SCI.

Key words: neural regeneration, spinal cord injury, olfactory ensheathing cells, cell transplantation, spinal cord transection, seed cells, Web of Science, bibliometrics, grants-supported paper, neuroregeneration