中国神经再生研究(英文版)

中国神经再生研究(英文版) ›› 2013, Vol. 8 ›› Issue (14): 1327-1336.doi: 10.3969/j.issn.1673-5374.2013.14.009

• 原著:退行性病与再生 • 上一篇    下一篇

贝叶斯网络证实多发性硬化患者日常活动能力与脑损伤部位有关

  

  • 收稿日期:2012-10-17 修回日期:2013-04-23 出版日期:2013-05-15 发布日期:2013-05-15

Activities of daily living and lesion position among multiple sclerosis patients by Bayes network

Zhifang Pan1, 2, Hongtao Lu1, Qi Cheng3, 4   

  1. 1 Department of Computer Science and Engineering, Shanghai Jiao Tong University, Shanghai 200240, China
    2 School of Information & Engineering, Wenzhou Medical College, Wenzhou 325035, Zhejiang Province, China
    3 School of Public Health, Shanghai Jiao Tong University, Shanghai 200025, China
    4 Department of Neurology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
  • Received:2012-10-17 Revised:2013-04-23 Online:2013-05-15 Published:2013-05-15
  • Contact: Zhifang Pan☆, Studying for doctorate, Associate professor, Department of Computer Science and Engineering, Shanghai Jiao Tong University, Shanghai 200240, China; School of Information & Engineering, Wenzhou Medical College, Wenzhou 325035, Zhejiang Province, China, panzhifang@hotmail.com. Qi Cheng, M.D., Ph.D., Professor, School of Public Health, Shanghai Jiao Tong University, Shanghai 200025, China; Department of Neurology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China, qicheng8@yahoo.com.cn.
  • Supported by:

    国家自然科学基金项目（No. 30872179，81070958）；上海市科委项目（No. 08410702200）；上海市重点学科项目（No. 08GWEX0201）

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摘要：

MRI对多发性硬化有很高的诊断敏感性，T2加权MRI也发现多发性硬化患者在大脑白质、灰质及脊髓中出现病变。但是，关于MRI的结果与残疾等级评分结果之间的关系目前研究较少，相关度很微弱。我们在1年期内，通过对中国上海的11个行政区进行大规模的多发性硬化流行病学调查，收集了上海地区进入协作网络医院的238例多发性硬化患者核磁共振扫描检查结果。通过贝叶斯网络概率计算发现了，多发性硬化患者的日常生活能力分级结果与大脑、脊髓、幕上等位置的病变明显相关，而与脑干的损伤关系不明确；与损伤部位的大小、性别、患者来源地也无关。

关键词: 神经再生, 神经退行性变, 多发性硬化, MRI, 贝叶斯网络, 日常生活能力, 流行病学调查, 基金资助文章

Abstract:

Magnetic resonance imaging is a highly sensitive approach for diagnosis of multiple sclerosis, and T2-weighted images can reveal lesions in the cerebral white matter, gray matter, and spinal cord. However, the lesions have a poor correlation with measurable clinical disability. In this study, we performed a large-scale epidemiological survey of 238 patients with multiple sclerosis in eleven districts by network member hospitals in Shanghai, China within 1 year. The involved patients were scanned for position and size of lesions by MRI. Results showed that lesions in the cerebrum, spinal cord, or supratentorial position had an impact on the activities of daily living in multiple sclerosis patients, as assessed by the Bayes network. On the other hand, brainstem lesions were very unlikely to influence the activities of daily living, and were not associated with the position of lesion, patient’s gender, and patient’s living place.

Key words: neural regeneration, neurodegenerative diseases, multiple sclerosis, magnetic resonance imaging, Bayes network, activities of daily living, epidemiological survey, grants-supported paper, neuroregeneration