中国神经再生研究(英文版)

中国神经再生研究(英文版) ›› 2013, Vol. 8 ›› Issue (26): 2432-2440.doi: 10.3969/j.issn.1673-5374.2013.26.004

• 原著:神经损伤修复保护与再生 • 上一篇    下一篇

新生儿胼胝体超声测量与早产儿的神经发育

  

  • 收稿日期:2013-05-04 修回日期:2013-05-04 出版日期:2013-09-15 发布日期:2013-09-15
  • 基金资助:

    河北省人口和计划生育委员会科研项目（No. 2008-B04）

Ultrasound measurement of the corpus callosum and neural development of premature infants

Fang Liu1, Shikao Cao2, Jiaoran Liu2, Zhifang Du2, Zhimei Guo2, Changjun Ren3   

  1. 1 Department of Pediatrics, NICU, Bethune International Peace Hospital, Shijiazhuang 050082, Hebei Province, China

    2 Department of Ultrasound, Bethune International Peace Hospital, Shijiazhuang 050082, Hebei Province, China

    3 Department of Pediatrics, NICU, the First Hospital of Hebei Medical University, Shijiazhuang 050051, Hebei Province, China
  • Received:2013-05-04 Revised:2013-05-04 Online:2013-09-15 Published:2013-09-15
  • Contact: Fang Liu, Ph.D., M.D., Professor, Department of Pediatrics, NICU, Bethune International Peace Hospital, Shijiazhuang 050082, Hebei Province, China, liufanglafy@126.com.
  • Supported by:

    This work was supported by the Hebei Province Population and the Family Planning Commission of Science and Technology Research Program in China, No. 2008-B04.

PDF

2163

摘要：

应用新生儿颅脑专用超声探头对152名新生儿于出生当天行超声检查，测量新生儿胼胝体正中矢状位长度、膝部厚度、体干部厚度、压部厚度及冠状位厚度。结果显示，随着孕周和体质量的增加，新生儿胼胝体长度、膝部厚度、压部厚度逐步增加，而其他指标变化不明显。提示胼胝体正中矢状位长度、膝部厚度、压部厚度适合超声实时评价早产儿胼胝体的发育。进一步分析发现男婴胼胝体体干部厚度、压部厚度以及胼胝体冠状位厚度大于女婴，说明胼胝体的大小在新生儿期有性别差异。对小于34周的早产儿于纠正胎龄40周时进行第2次颅脑超声胼胝体测量以及新生儿神经行为测定，发现校正胎龄40周新生儿神经行为评分与早产儿孕周和出生体质量及出生当天颅脑超声胼胝体长度、膝部厚度、压部厚度无关；但校正胎龄40周第2次胼胝体测量发现，新生儿神经行为评分异常的早产儿，其胼胝体长度、膝部厚度、压部厚度均小于新生儿神经行为评分正常的早产儿。可见在早产儿早期宫外生长阶段，胼胝体的生长与早产儿早期神经行为发育相关联。

关键词: 神经再生, 神经发生, 早产儿脑损伤, 颅脑超声, 新生儿, 早产儿, 胼胝体, 新生儿神经行为, 基金资助文章

Abstract:

Length and thickness of 152 corpus callosa were measured in neonates within 24 hours of birth. Using ultrasonic diagnostic equipment with a neonatal brain-specific probe, corpus callosum length and thickness of the genu, body, and splenium were measured on the standard mid-sagittal plane, and the anteroposterior diameter of the genu was measured in the coronal plane. Results showed that corpus callosum length as well as thickness of the genu and splenium increased with gesta-tional age and birth weight, while other measures did not. These three factors on the standard mid-sagittal plane are therefore likely to be suitable for real-time evaluation of corpus callosum de-velopment in premature infants using cranial ultrasound. Further analysis revealed that thickness of the body and splenium and the anteroposterior diameter of the genu were greater in male infants than in female infants, suggesting that there are sex differences in corpus callosum size during the neonatal period. A second set of measurements were taken from 40 premature infants whose ges-tational age was 34 weeks or less. Corpus callosum measurements were corrected to a gestational age of 40 weeks, and infants were grouped for analysis depending on the outcome of a neonatal behavioral neurological assessment. Compared with infants with a normal neurological assessment, corpus callosum length and genu and splenium thicknesses were less in those with abnormalities, indicating that corpus callosum growth in premature infants is associated with neurobehavioral de-velopment during the early extrauterine stage.

Key words: neural regeneration, neurogenesis, brain injury, premature infant, cranial ultrasound, neonate, corpus callosum, neonatal neurobehavior, grants-supported paper, neuroregeneration