中国神经再生研究(英文版)

中国神经再生研究(英文版) ›› 2013, Vol. 8 ›› Issue (29): 2775-2782.doi: 10.3969/j.issn.1673-5374.2013.29.009

• 原著:神经损伤修复保护与再生 • 上一篇    

热疗效应与脑恶性胶质瘤

  

  • 收稿日期:2013-05-28 修回日期:2013-07-20 出版日期:2013-10-15 发布日期:2013-10-15
  • 基金资助:

    黑龙江省留学归国基金（IC03C18 2003-2005）

Treatment of malignant glioma using hyperthermia

Jiahang Sun, Mian Guo, Hengyuan Pang, Jingtao Qi, Jinwei Zhang, Yunlong Ge   

  1. Department of Neurosurgery, the Second Affiliated Hospital of Harbin Medical University, Harbin 150000, Heilongjiang Province, China
  • Received:2013-05-28 Revised:2013-07-20 Online:2013-10-15 Published:2013-10-15
  • Contact: Yunlong Ge, M.D., Professor, Department of Neurosurgery, the Second Affiliated Hospital of Harbin Medical University, Harbin 150000, Heilongjiang Province, China, sunjiahang978675@sina. com.
  • About author:Jiahang Sun, Master, Attending physician.
  • Supported by:

    This study was financially sponsored by the Overseas Returnees of Heilongjiang Province in China, No. IC03C18 2003-2005.

PDF

1252

摘要：

实验纳入30例经手术病理或放置射频电极针时经病理诊断的3-4级原发或复发恶性胶质瘤患者，肿瘤直径3-7cm，将其随机等分为两组，对照组进行常规放化疗，热疗组原发患者仅进行热疗，复发患者在常规放化疗基础上进行热疗，热疗采用13.56 MHz的肿瘤射频热疗仪，在CT引导的立体定向仪下将电极针插入肿瘤中心部加热1h。热疗后3个月每月行头部CT或MRI检查，结果发现，与对照组比较，热疗组脑胶质瘤组织密度减低，表现为生长停滞或不生长，80%的肿瘤加热部分出现明显坏死、肿瘤直径缩小，表明射频热疗对恶性神经胶质瘤具有较好的治疗作用。

关键词: 神经再生, 脑胶质瘤, 射频热疗, 坏死, 恶性肿瘤, 复发, CT, MRI, 颅内高压, 临床疗效, 基金资助文章

Abstract:

Thirty pathologically diagnosed patients with grade III–IV primary or recurrent malignant glioma (tumor diameter 3–7 cm) were randomly divided into two groups. The control group underwent conventional radiotherapy and chemotherapy. In the hyperthermia group, primary cases received hyperthermia treatment, and patients with recurrent tumors were treated with hyperthermia in com-bination with radiotherapy and chemotherapy. Hyperthermia treatment was administered using a 13.56-MHz radio frequency hyperthermia device. Electrodes were inserted into the tumor with the aid of a CT-guided stereotactic apparatus and heat was applied for 1 hour. During 3 months after hyperthermia, patients were evaluated with head CT or MRI every month. Gliomas in the hyper-thermia group exhibited growth retardation or growth termination. Necrosis was evident in 80% of the heated tumor tissue and there was a decrease in tumor diameter. Our findings indicate that ra-dio frequency hyperthermia has a beneficial effect in the treatment of malignant glioma.

Key words: neural regeneration, glioma, radio frequency hyperthermia, necrosis, malignant tumor, recurrence, CT, MRI, intracranial hypertension, clinical effects, grants-supported paper, neuroregeneration