中国神经再生研究(英文版)

中国神经再生研究(英文版) ›› 2021, Vol. 16 ›› Issue (8): 1628-1637.doi: 10.4103/1673-5374.303032

• 原著:周围神经损伤修复保护与再生 • 上一篇    下一篇

神经科学领域坏死性凋亡研究趋势及热点和前景

  

  • 出版日期:2021-08-15 发布日期:2021-01-13
  • 基金资助:

    国家自然科学基金项目(81772134，81971891，81571939)；湖南省重点研究发展计划项目(2018SK2091)；湖南省研究生创新基金(CX20200116)；卫生部部长吴洁平医学基金(320.6750.14118)；湖南省科学技术基金(2018JJ2552)；中南大学研究生自主探索与创新计划项目(2020zzts218)。

Research trends, hot spots and prospects for necroptosis in the field of neuroscience

Wei-Tao Yan1, #, Shuang Lu1, #, Yan-Di Yang1, Wen-Ya Ning2, Yan Cai3, Xi-Min Hu1, Qi Zhang1, Kun Xiong1, 4, *#br#   

  1. 1Department of Anatomy and Neurobiology, School of Basic Medical Science, Central South University, Changsha, Hunan Province, China; 2Third Xiangya Hospital of Central South University, Changsha, Hunan Province, China; 3Department of Histology and Embryology, School of Basic Medical Science, Central South University, Changsha, Hunan Province, China; 4Hunan Key Laboratory of Ophthalmology, Changsha, Hunan Province, China
  • Online:2021-08-15 Published:2021-01-13
  • Contact: Kun Xiong, PhD, xiongkun2001@163.com.
  • Supported by:
    This work was supported by the National Natural Science Foundation of China, Nos. 81772134, 81971891, and 81571939 (to KX); the Key Research and Development Program of Hunan Province of China, No. 2018SK2091 (to KX); Hunan Provincial Innovation Foundation For Postgraduate, No. CX20200116 (to WTY); Wu JiePing Medical Foundation of the Minister of Health of China, No. 320.6750.14118 (to KX); Foundation of Science and Technology of Hunan Province of China, No. 2018JJ2552 (to YC); the Project of Graduate Independent Exploration and Innovation Plan of Central South University of China, No. 2020zzts218 (to WTY). 

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摘要：

细胞死亡的主要方式有2种，凋亡是由细胞信号通路调控的死亡，坏死是细胞由于环境压力导致的一种被动死亡方式。目前有研究证实，坏死也能受精确的细胞信号通路调控，这种死亡方式被命名为“坏死性凋亡”，坏死性凋亡已被发现与许多疾病的发生和发展有关。为此，文章运用文献计量学的方法，分析了2007-2019年全球神经科学领域中坏死性凋亡研究的文献产出趋势，以了解该领域的研究热点和前景。文章纳入了2007-2019年Web of Science数据库的坏死性凋亡研究相关文献145篇，参考文献2239篇。采用可视化分析发现：①坏死性凋亡研究相关出版物数量逐年增加，2019年达到峰值，发表文献数量最多的国家是中国；②关键词及文献分析表明，线粒体功能改变、脑卒中、缺血再灌注和神经炎症可能是坏死性凋亡的研究热点和未来发展方向，而免疫反应与其参与者的关系、损伤相关分子模式和病原体相关分子模式和坏死性凋亡的关系可能成为未来研究的热点。③总之，虽然文献计量学内在的局限性可能会影响文章对研究热点预测的准确性，但文章结果可为神经科学领域坏死性凋亡的研究提供参考依据。

https://orcid.org/0000-0002-3103-6028 (Kun Xiong)

关键词:

文献计量分析, 坏死性眼睑下垂, 神经科学, 沃斯维尔, 城市空间, 科学网, h指数, 网络分析, 输出, 引文

Abstract: There are two types of cell death-apoptosis and necrosis. Apoptosis is cell death regulated by cell signaling pathways, while necrosis has until recently been considered a passive mechanism of cell death caused by environmental pressures. However, recent studies show that necrosis can also be regulated by specific cell signaling pathways. This mode of death, termed necroptosis, has been found to be related to the occurrence and development of many diseases. We used bibliometrics to analyze the global output of literature on necroptosis in the field of neuroscience published in the period 2007–2019 to identify research hotspots and prospects. We included 145 necroptosis-related publications and 2239 references published in the Web of Science during 2007–2019. Visualization analysis revealed that the number of publications related to necroptosis has increased year by year, reaching a peak in 2019. China is the country with the largest number of publications. Key word and literature analyses demonstrated that mitochondrial function change, stroke, ischemia/reperfusion and neuroinflammation are likely the research hotspots and future directions of necroptosis research in the nervous system. The relationship between immune response-related factors, damage-associated molecular patterns, pathogen-associated molecular patterns and necroptosis may become a potential research hotspot in the future. Taken together, our findings suggest that although the inherent limitations of bibliometrics may affect the accuracy of the literature-based prediction of research hotspots, the results obtained from the included publications can provide a reference for the study of necroptosis in the field of neuroscience.

Key words: bibliometric analysis, citations, CiteSpace, h-index, necroptosis, network analysis, neuroscience, output, VOSviewer, Web of Science