中国神经再生研究(英文版)

中国神经再生研究(英文版) ›› 2013, Vol. 8 ›› Issue (31): 2942-2950.doi: 10.3969/j.issn.1673-5374.2013.31.007

• 原著:脑损伤修复保护与再生 • 上一篇    下一篇

大脑中动脉阻塞后远隔小脑继发性变化的磁共振表观弥散系数评价

  

  • 收稿日期:2013-07-20 修回日期:2013-10-05 出版日期:2013-11-05 发布日期:2013-11-05
  • 基金资助:

    浙江省科技计划项目（2012C37029）；浙江省公益性技术应用研究计划项目（2011C23021）

Apparent diffusion coefficient evaluation for secondary changes in the cerebellum of rats after middle cerebral artery occlusion

Yunjun Yang1, Lingyun Gao2, Jun Fu2, Jun Zhang1, Yuxin Li1, Bo Yin1, Weijian Chen2, Daoying Geng1   

  1. 1 Department of Radiology, Huashan Hospital, Fudan University, Shanghai 200040, China
    2 Department of Radiology, First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, Zhejiang Province, China
  • Received:2013-07-20 Revised:2013-10-05 Online:2013-11-05 Published:2013-11-05
  • Contact: Daoying Geng, Professor, Department of Radiology, Huashan Hospital, Fudan University, Shanghai 200040, China, wzmcyyunjun@163.com.
  • About author:Yunjun Yang, Ph.D., Associate professor. Yunjun Yang and Lingyun Gao contributed equally to this work.
  • Supported by:

    This study was supported by Zhejiang Province Science and Technology Plan Project in China, No. 2012C37029; Public Welfare Technology Application Research Plan Project of Zhejiang Province in China, No. 2011C23021.

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摘要：

脑梗死可引起远隔区域（如小脑）的功能抑制，可能与神经机能联系不能现象有关。该现象通常应用单光子发射计算机断层成像和正电子发射断层成像进行分析，但仪器的费用较贵且有辐射。实验首次通过动态观察表观弥散系数值量化单侧大鼠大脑中动脉阻塞后核心梗死区及远隔部位的变化。磁共振弥散加权成像显示，随梗死时间延长，大鼠梗死核心面积逐渐变大，信号增高，邻近皮质逐渐累及，24h信号变化趋于稳定；而表观弥散系数，大鼠梗死区表观弥散系数逐渐下降，而两侧小脑表观弥散系数亦下降，且均在梗死后3-24 h稍微上升。远隔部位表观弥散系数值随幕上梗死核心变化而改变，说明远隔部位存在神经机能联系不能现象，而且发现磁共振弥散加权成像与表观弥散系数值可以用于该现象的早期检测。

关键词: 神经再生, 脑损伤, 脑缺血, 脑梗死, 磁共振成像, 表观弥散系数, 大脑中动脉阻塞, 弥散加权成像, 梗死核心, 远隔区域, 神经机能联系, 基金资助文章

Abstract:

Supratentorial cerebral infarction can cause functional inhibition of remote regions such as the cerebellum, which may be relevant to diaschisis. This phenomenon is often analyzed using positron emission tomography and single photon emission CT. However, these methods are expensive and radioactive. Thus, the present study quantified the changes of infarction core and remote regions after unilateral middle cerebral artery occlusion using apparent diffusion coefficient values. Diffu-sion-weighted imaging showed that the area of infarction core gradually increased to involve the cerebral cortex with increasing infarction time. Diffusion weighted imaging signals were initially in-creased and then stabilized by 24 hours. With increasing infarction time, the apparent diffusion co-efficient value in the infarction core and remote bilateral cerebellum both gradually decreased, and then slightly increased 3–24 hours after infarction. Apparent diffusion coefficient values at remote regions (cerebellum) varied along with the change of supratentorial infarction core, suggesting that the phenomenon of diaschisis existed at the remote regions. Thus, apparent diffusion coefficient values and diffusion weighted imaging can be used to detect early diaschisis.

Key words: neural regeneration, brain injury, cerebral ischemia, cerebral infarction, magnetic resonance imaging, apparent diffusion coefficient, middle cerebral artery occlusion, diffusion weighted imaging, infarction core, remote regions, diaschisis, grants-supported paper, neuroregeneration