中国神经再生研究(英文版)

中国神经再生研究(英文版) ›› 2013, Vol. 8 ›› Issue (32): 2981-2990.doi: 10.3969/j.issn.1673-5374.2013.32.001

• 原著:脑损伤修复保护与再生 •    下一篇

不同部位慢性疼痛大脑结构差异：基于体素的形态学分析

  

  • 收稿日期:2013-06-28 修回日期:2013-09-28 出版日期:2013-11-15 发布日期:2013-11-15
  • 基金资助:

    国家自然科学基金项目(No. 30870686，81371530).

Differences in brain structure in patients with distinct sites of chronic pain A voxel-based morphometric analysis

Cuiping Mao1, Longxiao Wei1, Qiuli Zhang1, Xia Liao2, Xiaoli Yang2, Ming Zhang1   

  1. 1 Department of Radiology, the First Affiliated Hospital, School of Medicine, Xi’an Jiaotong University, Xi’an 710061, Shaanxi Province, China
    2 Department of Pain, the First Affiliated Hospital, School of Medicine, Xi’an Jiaotong University, Xi’an 710061, Shaanxi Province, China
  • Received:2013-06-28 Revised:2013-09-28 Online:2013-11-15 Published:2013-11-15
  • Contact: Ming Zhang, M.D., Chief physician, Department of Radiology, the First Affiliated Hospital, School of Medicine, Xi’an Jiaotong University,Xi’an 710061, Shaanxi Province, China, profzmmri@gmail.com. Xiaoli Yang, M.D., Chief physician, Department of Pain, the First Affiliated Hospital, School of Medicine, Xi’an Jiaotong University, Xi’an 710061, Shaanxi Province, China, pain67@163.com.
  • About author:Cuiping Mao, Studying for doctorate.
  • Supported by:

    This work was supported partially by two grants from the National Natural Science Foundation of China, No. 30870686 and 81371530.

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摘要：

多种慢性疼痛都会出现脑区灰质体积减少的现象，且这种灰质异常出现的区域一般在不同类型疼痛中的情况是不同的。为观察颈肩痛和腰背部疼痛患者脑形态的差异。我们使用了基于体素的MRI分析方法观察了不同疼痛部位的慢性腰背痛患者的大脑灰质变化。结果发现，腰背部疼痛患者大脑皮质灰质体积减少主要发生在左中央后回、左楔前区和双边椎体楔皮质；双侧壳核、伏隔核、右侧苍白球、右侧尾状核和左侧杏仁核皮质下灰质体积增加；上背部疼痛患者仅左侧中央皮质和左中央后皮质灰质体积减少。表明腰背部疼痛患者脑区灰质体积异常比上背部疼痛患者更广泛，颈肩痛和腰背部疼痛患者大脑皮质灰质体积减少，而皮质下灰质体积增加只发生在腰背部疼痛患者中。

关键词: 神经再生, 脑损伤, 慢性腰背部疼痛, 上背部疼痛, 基于体素的形态学测量, 灰质, 磁共振成像, 基底节, 萎缩, 慢性疼痛, 基金资助文章

Abstract:

A reduction in gray matter volume is common in patients with chronic back pain, and different types of pain are associated with gray matter abnormalities in distinct brain regions. To examine differences in brain morphology in patients with low back pain or neck and upper back pain, we investigated changes in gray matter volume in chronic back pain patients having different sites of pain using voxel-based morphometry. A reduction in cortical gray matter volume was found primarily in the left postcentral gyrus and in the left precuneus and bilateral cuneal cortex of patients with low back pain. In these patients, there was an increase in subcortical gray matter volume in the bilateral putamen and accumbens, right pallidum, right caudate nucleus, and left amygdala. In upper back pain patients, reduced cortical gray matter volume was found in the left precentral and left postcentral cortices. Our findings suggest that regional gray matter volume abnormalities in low back pain patients are more extensive than in upper back pain patients. Subcortical gray matter volume increases are found only in patients with low back pain.

Key words: neural regeneration, brain injury, chronic low back pain, upper back pain, voxel-based morphometry, gray matter, magnetic resonance imaging, basal ganglia, atrophy, chronic pain, grants-supported paper, neuroregeneration