中国神经再生研究(英文版) ›› 2014, Vol. 9 ›› Issue (2): 213-222.doi: 10.4103/1673-5374.125353

• 原著:退行性病与再生 • 上一篇    

针刺/电针加强帕罗西汀的抗抑郁效应:SCL-90评分证据

  

  • 收稿日期:2013-11-25 出版日期:2014-01-10 发布日期:2014-01-10
  • 基金资助:

    国家科技支撑计划课题(No.2006BAI12B05-2),国家自然科学基金(No.30672768), 广东省“211工程”三期重点学科建设项目

Acupuncture/electroacupuncture enhances anti-depressant effect of Seroxat: the Symptom Checklist-90 scores

Junqi Chen1, Weirong Lin2, Shengxu Wang3, Chongqi Wang3, Ganlong Li1, Shanshan Qu3, Yong Huang3, Zhangjin Zhang4, Wei Xiao3   

  1. 1 The Third Affiliated Hospital of Southern Medical University, Guangzhou, Guangdong Province, China
    2 The Shenzhen TCM Hospital, Shenzhen, Guangdong Province, China
    3 School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, Guangdong Province, China
    4 School of Chinese Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, China
  • Received:2013-11-25 Online:2014-01-10 Published:2014-01-10
  • Contact: Yong Huang, M.D., School of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, Guangdong Province, China,nfhy@fimmu.com. Zhangjin Zhang, M.D., School of Chinese Medicine, The University of Hong Kong, Hong Kong Special Administrative Region 999077, China, zhangzj@hku.hk. Wei Xiao, M.D., School of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, Guangdong Province, China, xw76888@126.com.
  • Supported by:

    This study was supported by the National Science and Technology Support Program of China, No. 2006BAI12B05-2; the National Natural Science Foundation of China, No. 30672768; Key Discipline Construction Project of “211 Project” of Guangdong Province in China.

摘要:

将105例原发性单相抑郁症患者随机分为3组,药物组给予盐酸帕罗西汀片治疗,手针和电针组在药物治疗的基础上进行针刺和电针治疗,针刺和电针治疗6周,3组给药至10周。分别于治疗前及治疗后2,4,6,10周应用症状自评量表SCL-90对患者的症状进行评估。结果显示,随着治疗时间的延长,3组患者SCL-90各因子分和总分均有不同程度下降,其中手针组和电针组SCL-90总分和强迫症状、抑郁、焦虑因子分降低较药物组更明显,但手针组和电针组SCL-90各因子分和总分比较差异均无显著性意义。同时结果发现,停止电针后,电针组的躯体化、抑郁、敌对、恐怖因子分较电针6周时稍高。可见单纯服用盐酸帕罗西汀片和与针刺/电针联合治疗原发性单相抑郁症均有显著的疗效,加用针刺/电针起效较快,对患者的总体症状、强迫、抑郁、焦虑症状改善更佳。

关键词: 神经再生, 针灸, 针刺, 电针, 选择性五羟色胺再摄取抑制剂, 帕罗西汀, 原发性单相抑郁症, SCL-90, 焦虑, NSFC

Abstract:

One hundred and five patients with primary unipolar depression were randomly divided into three groups: drug group (Seroxat administration), acupuncture group (Seroxat plus acupuncture), and electroacupuncture group (Seroxat plus acupuncture plus electroacupuncture). Patients’ symptoms were evaluated using a psychometric questionnaire, the Symptom Checklist-90, before intervention and after 2, 4, 6 and 10 weeks of treatment. The individual factor scores and the total score from the Symptom Checklist-90 reduced in all three groups as treatment progressed. In the acupuncture and electroacupuncture groups, the total score and the factor scores for obsessive-compulsive symptoms, depression, and anxiety were significantly lower than those in the drug group. There was no significant difference in the factor scores or total scores between the acupuncture and electroacupuncture groups. Some factor scores in the electroacupuncture group, such as somatization, depression, hostility, and phobic anxiety, were increased at 10 weeks compared with the respective score immediately after the course of electroacupuncture at 6 weeks. Our findings indicate that administration of Seroxat alone or in combination with acupuncture/electroacupuncture can produce a significant effect in patients with primary unipolar depression. Furthermore, acupuncture/electroacupuncture has a rapid onset of therapeutic effect and produces a noticeable improvement in obsessive-compulsive, depressive and anxiety symptoms.

Key words: nerve regeneration, acupuncture and moxibustion, electroacupuncture, selective serotonin reuptake inhibitor, Seroxat, primary unipolar depression, Symptom Checklist-90, anxiety, NSFC grant, neural regeneration