中国神经再生研究(英文版) ›› 2014, Vol. 9 ›› Issue (4): 407-412.doi: 10.4103/1673-5374.128246

• 原著:退行性病与再生 • 上一篇    下一篇

中药复方地黄可缓解帕金森病异动症

  

  • 收稿日期:2014-01-18 出版日期:2014-02-25 发布日期:2014-02-25

Compound Formula Rehmannia alleviates levodopa-induced dyskinesia in Parkinson’s disease

Long Teng, Fang Hong, Chenguang Zhang, Jiancheng He, Haiying Wang,   

  1. Shanghai University of Traditional Chinese Medicine, Shanghai, China
  • Received:2014-01-18 Online:2014-02-25 Published:2014-02-25
  • Contact: Jiancheng He, M.D., Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China, hejc8163@163.com. Haiying Wang, M.D., Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China, wanghaiying _7@hotmail.com.
  • Supported by:

    This study was supported by the National Natural Science Foundation of China, No. 30672684, 30973722; Science and Technology Support Traditional Chinese Drug Research and Development Project of Shanghai, No. F50102; Traditional Chinese Medicine Research Fund of Shanghai Municipal Health Bureau, No. 2012J009A; Annual Research Budget of Shanghai University of Traditional Chinese Medicine in 2013, No. 2013JW25.

摘要:

中药复方地黄方在临床应用中已被证实治疗帕金森病及异动症方面有满意疗效,但作用机制尚待证实。实验制备了帕金森病异动症模型大鼠并给其腹腔注射中药复方地黄方,结果显示抑制了纹状体兴奋性氨基酸类神经递质相关基因N-甲基-D-天冬氨酸受体亚基1,2的升高,阻止了抑制性氨基酸类神经递质基因γ-氨基丁酸受体B1表达的降低,减轻帕金森病异动症模型大鼠的异动症状。表明中药复方地黄方可能通过调节纹状体内氨基酸平衡,缓解帕金森病异动症的症状。

关键词: 神经再生, 中医药, 帕金森病, 异动症, 兴奋性氨基酸, 抑制性氨基酸, 神经行为学, 复方地黄方, 基金资助文章

Abstract:

Compound Formula Rehmannia has been shown to be clinically effective in treating Parkinson’s disease and levodopa-induced dyskinesia; however, the mechanisms remain unclear. In this study, we established a model of Parkinson’s disease dyskinesia in rats, and treated these animals with Compound Formula Rehmannia. Compound Formula Rehmannia inhibited the increase in mRNA expression of N-methyl-D-aspartate receptor subunits 1 and 2 and excitatory amino acid neurotransmitter genes, and it inhibited the reduction in expression of γ-aminobutyric acid receptor B1, an inhibitory amino acid neurotransmitter gene, in the corpus striatum. In addition, Compound Formula Rehmannia alleviated dyskinesia symptoms in the Parkinson’s disease rats. These experimental findings indicate that Compound Formula Rehmannia alleviates levodopa-induced dyskinesia in Parkinson’s disease by modulating neurotransmitter signaling in the corpus striatum.

Key words: nerve regeneration, traditional Chinese medicine, Parkinson’s disease, dyskinesia, excitatory amino acid, inhibitory amino acid, neurobehavior, Compound Formula Rehmannia, NSFC grant, neural regeneration