中国神经再生研究(英文版) ›› 2014, Vol. 9 ›› Issue (5): 549-554.doi: 10.4103/1673-5374.130082

• 原著:脑损伤修复保护与再生 • 上一篇    下一篇

磁刺激光明穴产生脑电信号样本熵的分析

  

  • 收稿日期:2014-01-19 出版日期:2014-03-12 发布日期:2014-03-12
  • 基金资助:

    国家自然科学基金31100711,51377045,31300818;河北省自然科学基金H2013202176

Analysis of the effect of repeated-pulse transcranial magnetic stimulation at the Guangming point on electroencephalograms

Xin Zhang 1, Lingdi Fu 2, Yuehua Geng 2, Xiang Zhai 3, Yanhua Liu 4   

  1. 1 Tianjin Polytechnic University, Tianjin, China
    2 Province-Ministry Joint Key Laboratory of Electromagnetic Field and Electrical Apparatus Reliability, Hebei University of Technology, Tianjin, China
    3 Department of Otorhinolaryngology, Tianjin Huanhu Hospital, Tianjin, China
    4 Hebei College of Industry and Technology, Shijiazhuang, Hebei Province, China
  • Received:2014-01-19 Online:2014-03-12 Published:2014-03-12
  • Contact: Yuehua Geng, Ph.D., Province-Ministry Joint Key Laboratory of Electromagnetic Field and Electrical Apparatus Reliability, Hebei University of Technology, Tianjin 300130, China, 2522625@qq.com.
  • Supported by:

    This study was supported by the National Natural Science Foundation of China, No. 31100711, 51377045, 31300818; the Natural Science Foundation of Hebei Province, No. H2013202176.

摘要:

实验利用磁刺激系统对健康人左侧光明穴(GB37)进行重复脉冲磁刺激,并以非线性动力学方法分析磁刺激光明穴和非穴位点脑电信号样本熵值的特征,以及磁刺激光明穴前、中、后3个时期视觉刺激脑电信号样本熵值的特征进行比较。结果显示:磁刺激健康人光明穴与非穴位点时的脑电信号样本熵值在左额电极F3和右额电极FP2存在显著性差异,并且磁刺激光明穴样本熵值普遍高于磁刺激非穴位点样本熵值。对磁刺激光明穴之前和之后的样本熵值进行对比,受试者皮质顶区、中央区和右颞区5个电极C3、Cz、C4、P3、T8磁刺激前后样本熵值差异有显著性意义,磁刺激后C3、C4和P3电极样本熵值低于磁刺激前,而Cz、T8电极样本熵值高于磁刺激前。结果说明光明穴的磁刺激与对普通体表的磁刺激相比,在脑电信号方面存在特异性,主要表现在额区。磁刺激健康人光明穴前后,脑电信号变化显著,其机制可能与顶区、中央区和颞区脑电信号复杂性变化有关。

关键词: 神经再生, 脑损伤, 针刺, 磁刺激, 穴位, 非穴位点, 光明穴, 脑功能, 脑电信号, 复杂度, 样本熵, 非线性动力学

Abstract:

Here, we administered repeated-pulse transcranial magnetic stimulation to healthy people at the left Guangming (GB37) and a mock point, and calculated the sample entropy of electroencephalogram signals using nonlinear dynamics. Additionally, we compared electroencephalogram sample entropy of signals in response to visual stimulation before, during, and after repeated-pulse transcranial magnetic stimulation at the Guangming. Results showed that electroencephalogram sample entropy at left (F3) and right (FP2) frontal electrodes were significantly different depending on where the magnetic stimulation was administered. Additionally, compared with the mock point, electroencephalogram sample entropy was higher after stimulating the Guangming point. When visual stimulation at Guangming was given before repeated-pulse transcranial magnetic stimulation, significant differences in sample entropy were found at five electrodes (C3, Cz, C4, P3, T8) in parietal cortex, the central gyrus, and the right temporal region compared with when it was given after repeated-pulse transcranial magnetic stimulation, indicating that repeated-pulse transcranial magnetic stimulation at Guangming can affect visual function. Analysis of electroencephalogram revealed that when visual stimulation preceded repeated pulse transcranial magnetic stimulation, sample entropy values were higher at the C3, C4, and P3 electrodes and lower at the Cz and T8 electrodes than visual stimulation followed preceded repeated pulse transcranial magnetic stimulation. The findings indicate that repeated-pulse transcranial magnetic stimulation at the Guangming evokes different patterns of electroencephalogram signals than repeated-pulse transcranial magnetic stimulation at other nearby points on the body surface, and that repeated-pulse transcranial magnetic stimulation at the Guangming is associated with changes in the complexity of visually evoked electroencephalogram signals in parietal regions, central gyrus, and temporal regions.

Key words: nerve regeneration, brain injury, acupuncture, magnetic stimulation, acupuncture poi-nt, mock point, Guangming point, brain function, electroencephalogram signals, complexity, sample entropy, nonlinear dynamics, NSFC grant, neural regeneration

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