中国神经再生研究(英文版) ›› 2014, Vol. 9 ›› Issue (11): 1163-1168.doi: 10.4103/1673-5374.135319

• 原著:退行性病与再生 • 上一篇    

针刺老年轻度认知障碍患者太溪穴后可激活脑神经元

  

  • 收稿日期:2014-05-09 出版日期:2014-06-12 发布日期:2014-06-12
  • 基金资助:

    国家自然科学基金面上项目 (81173354);广东省自然基金 (10451810101005862);广东省中医药管理局课题(20111032,20132019);深圳科技计划(201302162)

Acupuncture at the Taixi (KI3) acupoint activates cerebral neurons in elderly patients with mild cognitive impairment

Shangjie Chen 1, 2, Maosheng Xu 3, Hong Li 4, Jiuping Liang 2, Liang Yin 3, Xia Liu 2, Xinyan Jia 1, Fen Zhu 1, Dan Wang 1, Xuemin Shi 2, Lihua Zhao 5   

  1. 1 Department of Rehabilitation, Baoan Hospital, Southern Medical University, Shenzhen, Guangdong Province, China
    2 Department of Acupuncture and Moxibustion, First Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China
    3 Department of Imaging, Baoan Hospital, Southern Medical University, Shenzhen, Guangdong Province, China
    4 School of Chinese Medicine, Hong Kong Baptist University, Hong Kong Special Administrative Region, China
    5 College of Acupuncture and Moxibustion, Guangxi University of Traditional Chinese Medicine, Nanning, Guangxi Zhuang Autonomous Region, China
  • Received:2014-05-09 Online:2014-06-12 Published:2014-06-12
  • Contact: Lihua Zhao, M.D., College of Acupuncture and Moxibustion, Guangxi University of Traditional Chinese Medicine, Nanning, Guangxi Zhuang Autonomous Region, China, zhaolh67@163.com.
  • Supported by:

    This study was supported by the National Natural Science Foundation of China, No. 81173354; the Natural Science Foundation of Guangdong Province, No. 10451810101005862; a grant from Guangdong Administration of Traditional Chinese Medicine, No. 20111032, 20132019; the Science and Technology Plan Project of Baoan District, Shenzhen City, No. 200902159.

摘要:

本课题组以往研究发现,针刺健康青年人太溪穴能使与认知功能相关的脑区神经元激活。那么,针刺轻度认知障碍老年患者太溪穴对脑神经元激活会同样的影响吗?实验应用静息态与任务态相融合的功能磁共振检测,见针刺健康老年人和轻度认知障碍患者的针感比较差异无显著性意义。针刺老年轻度认知障碍患者与健康老年人太溪穴脑神经元激活区有20个,包括左前扣带回的BA 32、24,左额内侧回的BA 9、10、11,左大脑枕叶的楔叶BA 19,左大脑额叶额中回的BA 11,右大脑边缘叶前扣带回BA 32、24,左大脑枕叶舌回BA 18,右大脑额叶额中回的BA 11,左大脑额叶额下回的BA 47, 左大脑额叶额上回的BA 11,右大脑额叶额下回BA 47,右大脑枕叶楔叶BA 19、18,右大脑颞叶颞上回BA 38,左大脑额叶胼胝下回BA 47,左大脑顶叶楔前叶BA 19,右大脑额叶额内侧回BA 10,右大脑额叶额上回BA 11,左大脑边缘叶扣带回BA 32,右大脑顶叶楔前叶BA 19,左大脑额叶中央前回BA 6,右大脑枕叶梭状回(枕颞内侧回)BA 19。结果表明,针刺老年轻度认知障碍患者太溪穴也可使认知功能相关区域的脑神经元激活。

关键词: 神经再生, 针刺, 穴位, 太溪穴, 穴位特异性, 轻度认知障碍, 功能磁共振, 静息, 认知功能, 脑功能, 针感, 国家自然科学基金

Abstract:

Our previous findings have demonstrated that acupuncture at the Taixi (KI3) acupoint in healthy youths can activate neurons in cognitive-related cerebral cortex. Here, we investigated whether acupuncture at this acupoint in elderly patients with mild cognitive impairment can also activate neurons in these regions. Resting state and task-related functional magnetic resonance imaging showed that the pinprick senstation of acupuncture at the Taixi acupoint differed significantly between elderly patients with mild cognitive impairment and healthy elderly controls. Results showed that 20 brain regions were activated in both groups of participants, including the bilateral anterior cingulate gyrus (Brodmann areas [BA] 32, 24), left medial frontal cortex (BA 9, 10, 11), left cuneus (BA 19), left middle frontal gyrus (BA 11), left lingual gyrus (BA 18), right medial frontal gyrus (BA 11), bilateral inferior frontal gyrus (BA 47), left superior frontal gyrus (BA11), right cuneus (BA 19, 18), right superior temporal gyrus (BA 38), left subcallosal gyrus (BA 47), bilateral precuneus (BA 19), right medial frontal gyrus (BA 10), right superior frontal (BA 11), left cingulate gyrus (BA 32), left precentral gyrus (BA 6), and right fusiform gyrus (BA 19). These results suggest that acupuncture at the Taixi acupoint in elderly patients with mild cognitive impairment can also activate some brain regions.