Bone marrow mesenchymal stem cell transplantation has been shown to be therapeutic in the repair of spinal cord injury. However, the low survival rate of transplanted bone marrow mesenchymal stem cells in vivo remains a problem. Neurotrophin-3 promotes motor neuron survival and it is hypothesized that its transfection can enhance the therapeutic effect. Dr. Yuzhen Dong and co-workers from the First Affiliated Hospital of Xinxiang Medical College in China show that in vitro transfection of neurotrophin-3 gene increases the number of bone marrow mesenchymal stem cells in the region of spinal cord injury and inhibits apoptosis of motor neurons in the spinal anterior horn, with better outcomes than simple transplantation of bone marrow mesenchymal stem cells. This relevant article has been published in the Neural Regeneration Research (Vol. 9, No. 16, 2014).
Article: "Transplantation of neurotrophin-3-transfected bone marrow mesenchymal stem cells for the repair of spinal cord injury" by Yuzhen Dong, Libin Yang, Lin Yang, Hongxing Zhao, Chao Zhang, Dapeng Wu (Department of Orthopedics, the First Affiliated Hospital of Xinxiang Medical College, Weihui, Henan Province, China)
Dong YZ, Yang LB, Yang L, Zhao HX, Zhang C, Wu DP. Transplantation of neurotrophin-3-transfected bone marrow mesenchymal stem cells for the repair of spinal cord injury. Neural Regen Res. 2014;9(16):1520-1524.
Contact: Meng Zhao
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Neural Regeneration Research
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