中国神经再生研究(英文版) ›› 2014, Vol. 9 ›› Issue (16): 1557-1566.doi: 10.4103/1673-5374.139483

• 综述:退行性病与再生 • 上一篇    下一篇

浆果类植物对神经退行性疾病的神经保护效应

  

  • 收稿日期:2014-07-02 出版日期:2014-08-22 发布日期:2014-08-22
  • 基金资助:

    阿曼研究委员会资助项目(RC/AGR/FOOD/11/01)

Neuroprotective effects of berry fruits on neurodegenerative diseases

Selvaraju Subash 1, 2, Musthafa Mohamed Essa 1, 2, Samir Al-Adawi 2, 3, Mushtaq A. Memon 4, Thamilarasan Manivasagam 5, Mohammed Akbar 6   

  1. 1 Department of Food Science and Nutrition, College of Agricultural and Marine Sciences, Sultan Qaboos University, Muscat, Sultanate of Oman
    2 Ageing and Dementia Research Group, Sultan Qaboos University, Muscat, Sultanate of Oman
    3 College of Medicine and Health Sciences, Sultan Qaboos University, Muscat, Sultanate of Oman
    4 College of Veterinary Medicine, Washington State University, Pullman, WA, USA
    5 Department of Biochemistry and Biotechnology, Annamalai University, Tamilnadu, India
    6 Section of Molecular Pharmacology and Toxicology, Laboratory of Membrane Biochemistry and Biophysics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Rockville, MD, USA
  • Received:2014-07-02 Online:2014-08-22 Published:2014-08-22
  • Contact: Musthafa Mohamed Essa, Ph.D., Department of Food Science and Nutrition, P.O. 34, College of Agricultural and Marine Sciences, Sultan Qaboos University, Al-Khoud, Muscat, P.C. 123, Sultanate of Oman, drmdessa@squ.edu.om.
  • Supported by:

    This study was supported by a grant from the Research Councial of Sultanate of Oman, No. RC/AGR/FOOD/11/01.

摘要:

最近的临床试验证实浆果有预防衰老相关神经退行性疾病,改善运动和认知功能作用。浆果还有调节炎症,改善细胞存活涉及的信号通路,提高神经可塑性的作用。浆果对大脑神经退行性变的保护作用与其含有植物化学成分花青素、咖啡酸、 槲皮黄酮、山柰酚、丹宁酸有关。文章旨在综述浆果类植物作为神经退行性疾病神经保护剂的潜力效应。

关键词: 浆果, 神经退行性疾病, 神经保护, 阿尔茨海默病, 帕金森病, 综述

Abstract:

Recent clinical research has demonstrated that berry fruits can prevent age-related neurodegenerative diseases and improve motor and cognitive functions. The berry fruits are also capable of modulating signaling pathways involved in inflammation, cell survival, neurotransmission and enhancing neuroplasticity. The neuroprotective effects of berry fruits on neurodegenerative diseases are related to phytochemicals such as anthocyanin, caffeic acid, catechin, quercetin, kaempferol and tannin. In this review, we made an attempt to clearly describe the beneficial effects of various types of berries as promising neuroprotective agents.