中国神经再生研究(英文版)

中国神经再生研究(英文版) ›› 2014, Vol. 9 ›› Issue (20): 1850-1858.doi: 10.4103/1673-5374.143434

• 原著:脊髓损伤修复保护与再生 • 上一篇    

嗅鞘细胞移植促进脊髓全横断模型大鼠损伤后运动神经功能恢复的Meta分析

  

  • 收稿日期:2014-06-20 出版日期:2014-10-25 发布日期:2014-10-25

Meta analysis of olfactory ensheathing cell transplantation promoting functional recovery of motor nerves in rats with complete spinal cord transection

Jun Liu 1, Ping Chen 2, Qi Wang 1, Yu Chen 1, Hailong Yu 1, Junxiong Ma 1, Mingming Guo 1, Meihui Piao 1, Weijian Ren 1, Liangbi Xiang 1   

  1. 1 Department of Orthopedics, General Hospital of Shenyang Military Command Area of Chinese PLA, Shenyang, Liaoning Province, China 
    2 Department of Gastroenterology, Taian Central Hospital, Taian, Shandong Province, China
  • Received:2014-06-20 Online:2014-10-25 Published:2014-10-25
  • Contact: Liangbi Xiang, M.D., Department of Orthopedics, General Hospital of Shenyang Military Command Area of Chinese PLA, Shenyang 110840, Liaoning Province, China, xiangliangbi1963@sina.com.

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摘要：

目的：探索嗅鞘细胞移植对大鼠脊髓完全横断损伤的治疗效果。
资料来源：收集MEDLINE（1989/2013）、Embase（1989/2013）、Cochrane图书馆（1989/2013）、中国生物医学文献数据库（1989/2013）、CNKI（1989/2013）、维普数据库（1989/2013）、万方数据库（1989/2013）和中国临床试验注册中心的资料。
资料选择：选择使用嗅鞘细胞和另一种方法移植治疗脊髓完全横断损伤模型大鼠的随机对照试验，统计分析采用RevMan4.2.2软件。
主要观察指标：脊髓完全横断损伤模型大鼠的BBB评分。
结果：共纳入6个高质量的随机对照试验。与对照组相比，以嗅鞘细胞移植治疗的脊髓完全横断损伤模型大鼠BBB评分更高(WMD=3.16，95％CI(1.68, 4.65)，P < 0.00001)。
结论：嗅鞘细胞移植可促进脊髓完全横断模型大鼠运动神经功能的恢复。

关键词: 神经再生, 嗅鞘细胞, 细胞移植, 脊髓损伤, 完全切断脊髓损伤, BBB评分, Meta分析

Abstract:

OBJECTIVE: To evaluate the effects of olfactory ensheathing cell transplantation on functional recovery of rats with complete spinal cord transection.
DATA SOURCES: A computer-based online search of Medline (1989–2013), Embase (1989–2013), Cochrane library (1989–2013), Chinese Biomedical Literature Database (1989–2013), China National Knowledge Infrastructure (1989–2013), VIP (1989–2013), Wanfang databases (1989–2013) and Chinese Clinical Trial Register was conducted to collect randomized controlled trial data regarding olfactory ensheathing cell transplantation for the treatment of complete spinal cord transection in rats.
SELECTION CRITERIA: Randomized controlled trials investigating olfactory ensheathing cell transplantation and other transplantation methods for promoting neurological functional recovery of rats with complete spinal cord transection were included in the analysis. Meta analysis was conducted using RevMan 4.2.2 software.
MAIN OUTCOME MEASURES: Basso, Beattie and Bresnahan scores of rats with complete spinal cord transection were evaluated in this study.
RESULTS: Six randomized controlled trials with high quality methodology were included. Meta analysis showed that Basso, Beattie and Bresnahan scores were significantly higher in the olfactory ensheathing cell transplantation group compared with the control group (WMD = 3.16, 95% CI (1.68, 4.65); P < 0.00001).
CONCLUSION: Experimental studies have shown that olfactory ensheathing cell transplantation can promote the functional recovery of motor nerves in rats with complete spinal cord transection

Key words: nerve regeneration, olfactory ensheathing cells, cell transplantation, spinal cord injury, complete transection, BBB scores, meta analysis