关键词: 神经再生, 脑损伤, 认知神经科学, 事件相关电位, P300, 电生理, 营养状态, 微意识状态, 意识, 意识障碍, 无意识, 评价, 预后, 国家自然科学基金

Abstract:

The residual consciousness of unconscious patients can be detected by studying the P300, a wave among event-related potentials. Previous studies have applied tones, the subject’s name and other names as stimuli. However, the results were not satisfactory. In this study, we changed the constituent order of subjects’ two-character names to create derived names. The subject’s derived names, together with tones and their own names, were used as auditory stimuli in event-related potential experiments. Healthy controls and unconscious patients were included in this study and made to listen to these auditory stimuli. In the two paradigms, a sine tone followed by the subject’s own name and the subject’s derived name followed by the subject’s own name were used as standard and deviant stimuli, respectively. The results showed that all healthy controls had the P300 using both paradigms, and that the P300 in the second paradigm had a longer latency and two peaks. All minimally conscious state patients had the P300 in the first paradigm and the majority of them had the P300 in the second paradigm. Most vegetative state patients had no P300. Patients who showed the P300 in the two paradigms had more residual consciousness, and patients with the two-peak P300 had a higher probability of awakening within a short time. Our experimental findings suggest that the P300 event-related potential could reflect the conscious state of unconscious patients.

Key words: nerve regeneration, brain injury, cognitive neuroscience, event-related potential, P300, electrophysiology, nutritional state, minimally conscious state, consciousness, disorders of consciousness, unconsciousness, evaluation, prognosis, NSFC grants, neural regeneration