中国神经再生研究(英文版) ›› 2015, Vol. 10 ›› Issue (11): 1869-1873.doi: 10.4103/1673-5374.170319

• 原著:周围神经损伤修复保护与再生 • 上一篇    下一篇

猪脊神经根和脊支拉伸及应力松弛测试的力学特性

  

  • 收稿日期:2015-08-10 出版日期:2015-12-07 发布日期:2015-12-07

Mechanical properties of nerve roots and rami radiculares isolated from fresh pig spinal cords

Norihiro Nishida1, *, Tsukasa Kanchiku1, Junji Ohgi2, Kazuhiko Ichihara3, Xian Chen4, Toshihiko Taguchi5   

  1. 1 Department of Orthopedic Surgery, Yamaguchi University Graduate School of Medicine, Yamaguchi, Japan
    2 Faculty of Engineering, Yamaguchi University, Yamaguchi, Japan
    3 Non-Profit Organization Corporation, Japan Orthopedic Biomechanics Institute, Yamaguchi, Japan
    4 Faculties of Engineering, Yamaguchi University, Yamaguchi, Japan
    5 Department of Orthopedic Surgery, Yamaguchi University Graduate School of Medicine, Yamaguchi, Japan
  • Received:2015-08-10 Online:2015-12-07 Published:2015-12-07
  • Contact: Norihiro Nishida, M.D.,nishida3@yamaguchi-u.ac.jp.

摘要:

马尾综合征发病后的症状除与复杂的解剖结构和压迫方式有关外,还与马尾力学强度有关。因而实验应用单轴拉伸测试检测脊髓神经根和脊支强度特性,并分析应力-应变的关系及应变与强度的关系。实验中,分离自猪脊髓的脊神经根和脊支在加载应变率为0.1, 1, 10, and 100 s-1的条件下行拉伸测试和应力松弛测试。脊神经根的拉伸强度不随加载应变率的增大而增高,而脊支随加载应变率的增大而降低。实验结果为马尾综合征、神经根病和脊髓圆锥病变发病机制研究添加了生物力学变化的参考依据。

关键词: 马尾综合征, 单轴拉伸测试检, 应力-应变关系, 腰椎管狭窄, 截瘫, 脊髓

Abstract:

No reports have described experiments designed to determine the strength characteristics of spinal nerve roots and rami radiculares for the purpose of explaining the complexity of symptoms of medullary cone lesions and cauda equina syndrome. In this study, to explain the pathogenesis of cauda equina syndrome, monoaxial tensile tests were performed to determine the strength characteristics of spinal nerve roots and rami radiculares, and analysis was conducted to evaluate the stress-strain relationship and strength characteristics. Using the same tensile test device, the nerve root and ramus radiculares isolated from the spinal cords of pigs were subjected to the tensile test and stress relaxation test at load strain rates of 0.1, 1, 10, and 100 s–1 under identical settings. The tensile strength of the nerve root was not rate dependent, while the ramus radiculares tensile strength tended to decrease as the strain rate increased. These findings provide important insights into cauda equina symptoms, radiculopathy, and clinical symptoms of the medullary cone.

Key words: nerve regeneration, cauda equina syndrome, monoaxial tensile tests, radiculopathy, strength characteristics, stress-strain relationship, lumbar spinal canal stenosis, paralysis, spinal cord, neural degeneration