中国神经再生研究(英文版) ›› 2017, Vol. 12 ›› Issue (2): 329-336.doi: 10.4103/1673-5374.200816

• 综述:脑损伤修复保护与再生 • 上一篇    

高压氧预处理的抗炎抗氧化作用:改善术后认知功能障碍

  

  • 收稿日期:2016-12-22 出版日期:2017-02-15 发布日期:2017-02-15
  • 基金资助:

    2013年高等学校博士学科点专项科研基金联合资助课题(20133420110009)

Hyperbaric oxygen preconditioning improves postoperative cognitive dysfunction by reducing oxidant stress and inflammation

Zhi-xin Gao, Jin Rao, Yuan-hai Li   

  1. Department of Anesthesiology, First Affiliated Hospital of Anhui Medical University, Hefei, Anhui Province, China
  • Received:2016-12-22 Online:2017-02-15 Published:2017-02-15
  • Contact: Yuan-hai Li, M.D., Ph.D.,liyuanhai-1@163.com.
  • Supported by:

    This study was supported by the Special Research Foundation of Doctoral Course in Colleges and Universities of China in 2013, No. 20133420110009.

摘要:

如何改善术后认知功能障碍或预防其发生已经成为一个棘手的公共健康问题,目前尚无有效的解决方法。由于已有研究证实高压氧预处理对心,肝,脑等重要脏器有保护作用,因此很多研究者开始聚焦于用高压氧预处理来改善术后认知功能障碍,而对高压氧预处理能够改善术后认知功能障碍的机制认识存在争议。文章总结和综述了近年来高压氧预处理的应用、术后认知功能障碍危害性及发生机制,以及高压氧预处理改善术后认知功能障碍的作用机制。结论为高压氧预处理是一种有效可行的预防、减轻和改善术后认知功能障碍的方法,其作用机制涉及其可激发体内产生内源性的抗炎抗氧化效应,而发挥作用。

ORCID:0000-0001-6763-9624(Yuan-hai Li)

关键词: 神经再生, 脑损伤, 高压氧, 预处理, 抗氧化物, 抗炎作用, 活性氧, 氧化应激, 炎症反应, 保护作用, 术后, 认知功能障碍

Abstract:

Postoperative cognitive dysfunction is a crucial public health issue that has been increasingly studied in efforts to reduce symptoms or prevent its occurrence. However, effective advances remain lacking. Hyperbaric oxygen preconditioning has proved to protect vital organs, such as the heart, liver, and brain. Recently, it has been introduced and widely studied in the prevention of postoperative cognitive dysfunction, with promising results. However, the neuroprotective mechanisms underlying this phenomenon remain controversial. This review summarizes and highlights the definition and application of hyperbaric oxygen preconditioning, the perniciousness and pathogenetic mechanism underlying postoperative cognitive dysfunction, and the effects that hyperbaric oxygen preconditioning has on postoperative cognitive dysfunction. Finally, we conclude that hyperbaric oxygen preconditioning is an effective and feasible method to prevent, alleviate, and improve postoperative cognitive dysfunction, and that its mechanism of action is very complex, involving the stimulation of endogenous antioxidant and anti-inflammation defense systems.

Key words: nerve regeneration, brain injury, hyperbaric oxygenation, preconditioning, antioxidants, anti-inflammation, reactive oxygen species, oxidant stress, inflammation, protection, post-operation, cognitive dysfunction, neural regeneration