中国神经再生研究(英文版)

中国神经再生研究(英文版) ›› 2017, Vol. 12 ›› Issue (4): 603-609.doi: 10.4103/1673-5374.205102

• 原著:脑损伤修复保护与再生 • 上一篇    下一篇

扩散张量成像可以判断缺氧缺血性脑病新生儿的脑白质损伤

  

  • 收稿日期:2017-02-13 出版日期:2017-04-15 发布日期:2017-04-15
  • 基金资助:

    江苏省临床医学科技项目（BL2014037）；常州市科技支撑项目（CE20165027）；常州市卫生计生委重大项目（ZD201515）；常州市三级卫生个人培训项目

Diffusion tensor imaging assesses white matter injury in neonates with hypoxic-ischemic encephalopathy

Hong-xin Li1, 2, Xing Feng1, Qian Wang3, Xuan Dong4, Min Yu5, Wen-juan Tu2   

  1. 1 Department of Neonatology, Children’s Hospital of Soochow University, Suzhou, Jiangsu Province, China; 2 Department of Neonatology, Changzhou Children’s Hospital, Changzhou, Jiangsu Province, China; 3 School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China; 4 Department of Children’s Health Research Center, Changzhou Children’s Hospital, Changzhou, Jiangsu Province, China; 5 Nantong University, Nantong, Jiangsu Province, Chin
  • Received:2017-02-13 Online:2017-04-15 Published:2017-04-15
  • Contact: Xing Feng, M.D., xing_feng66@hotmail.com.
  • Supported by:

    This study was supported by a grant from the Clinical Medicine Science and Technology Projects in Jiangsu Province of China, No. BL2014037; a grant from the Changzhou City Science and Technology Support Plan in China, No. CE20165027; a grant from the Changzhou Health Development Planning Commission Major Projects in China, No. ZD201515; the Changzhou High-Level Health Personnel Training Project Funding.

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摘要：

随着危重症新生儿抢救水平的提高，越来越多的患儿得以存活，因而急需在早期阶段客观定量评估缺氧缺血性脑病患儿的预后。头颅CT、超声和传统MRI虽有助于诊断脑损伤，但不能评价脑白质损害。试验通过对10例无脑损伤足月新生儿及22例缺氧缺血性脑病新生儿（中度14例、重度8例）进行扩散张量成像检测，验证其评价缺血缺氧性脑病脑白质损伤的可行性。结果显示中度和重度缺氧缺血性脑病新生儿及正常新生儿部分脑区分数各向异性、像素数及纤维束数量存在差异，且内囊后支区分数各向异性与新生儿行为神经评分的相关性远高于其他脑区。说明扩散张量成像可以判断缺氧缺血性脑病新生儿的脑白质损伤。

ORCID:0000-0003-0519-3780(Xing Feng)

关键词: 神经再生, 分数各向异性, 扩散张量成像, 表观扩散系数, 像素数, 新生儿行为神经评分, 脑损伤, 脑白质, 影像学

Abstract:

With improvements in care of at-risk neonates, more and more children survive. This makes it increasingly important to assess, soon after birth, the prognosis of children with hypoxic-ischemic encephalopathy. Computed tomography, ultrasound, and conventional magnetic resonance imaging are helpful to diagnose brain injury, but cannot quantify white matter damage. In this study, ten full-term infants without brain injury and twenty-two full-term neonates with hypoxic-ischemic encephalopathy (14 moderate cases and 8 severe cases) underwent diffusion tensor imaging to assess its feasibility in evaluating white matter damage in this condition. Results demonstrated that fractional anisotropy, voxel volume, and number of fiber bundles were different in some brain areas between infants with brain injury and those without brain injury. The correlation between fractional anisotropy values and neonatal behavioral neurological assessment scores was closest in the posterior limbs of the internal capsule. We conclude that diffusion tensor imaging can quantify white matter injury in neonates with hypoxic-ischemic encephalopathy.

Key words: nerve regeneration, fractional anisotropy, diffusion tensor imaging, apparent diffusion coefficient, voxel volume, neonatal behavioral neurological assessment, brain injury, white matter, neuroimaging, neural regeneration