中国神经再生研究(英文版)

中国神经再生研究(英文版) ›› 2017, Vol. 12 ›› Issue (6): 1003-1008.doi: 10.4103/1673-5374.208597

• 综述:脊髓损伤修复保护与再生 • 上一篇    

聚乙二醇可作为修复脊髓损伤的潜在合成材料

  

  • 收稿日期:2017-04-05 出版日期:2017-06-15 发布日期:2017-06-15
  • 基金资助:

    国家重大科技研究发展项目（2016YFC1101500），国家自然科学基金（11672332）

Polyethylene glycol as a promising synthetic material for repair of spinal cord injury

Xian-bin Kong1, 2, Qiu-yan Tang3, Xu-yi Chen3, Yue Tu3, Shi-zhong Sun3, Zhong-lei Sun4   

  1. 1 Department of Brain, Affiliated Hospital of China Logistics College of People’s Armed Police Forces, Tianjin, China; 2 Tianjin University of Traditional Chinese Medicine, Tianjin, China; 3 Tianjin Key Laboratory of Neurological Trauma Repair, Tianjin, China; 4 Jinzhou Medical University, Jinzhou, Liaoning Province, China
  • Received:2017-04-05 Online:2017-06-15 Published:2017-06-15
  • Contact: Xu-yi Chen, M.D. or Yue Tu, M.D. or Shi-zhong Sun,Chenxuyi1979@126.com or ytumail@vip.126.com or loveicu@126.com.
  • Supported by:

    This study was supported by a grant from National Key Science and Technology Research & Development Plan in China, No. 2016YFC1101500; the National Natural Science Foundation of China, No. 11672332.

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摘要：

 

聚乙二醇是一类人工合成的可降解水溶性聚醚材料，具有良好的生物学性能和材料特性，在脊髓组织工程中具有良好的应用前景。目前有已有一些采用聚乙二醇修复脊髓损伤的研究报道，但具体修复效果尚不统一。文章检索国内外相关文献，阐述了聚乙二醇修复脊髓损伤的近年研究热点：(1) 聚乙二醇是可调节的生物分子载体，能够在脊髓损伤急性期对抗神经纤维溃变、减轻炎症反应、抑制空泡和瘢痕形成，具有神经膜保护的能力。(2) 聚乙二醇相关聚合物不仅促进血管再生，而且能搭载药物到达脊髓损伤部位，甚至载药通过血脊屏障及血脑屏障，在药物载体领域用途广泛。(3)聚乙二醇水凝胶也可作为损伤部位干细胞植入后生长的支持基质，诱导细胞迁移、增殖、分化，同时隔离或减少局部胶质瘢痕侵入，促进和导向轴突再生并穿越移植区域，与靶组织重新建立突触联系，促进脊髓修复。综合以往研究观点发现，聚乙二醇可作为应用于临床的修复脊髓损伤有发展潜力的合成材料。

ORCID:0000-0002-6293-1340(Xu-yi Chen)；0000-0003-2645-0168(Yue Tu)；0000-0002-0430-8980(Shi-zhong Sun)

关键词: 神经再生, 脊髓损伤, 聚乙二醇, 神经组织工程, 生物材料, 脊神经修复, 生物药物, 血脊髓屏障, 神经干细胞, 载体, 细胞培养

Abstract:

Polyethylene glycol is a synthetic, biodegradable, and water-soluble polyether. Owing to its good biological and material properties, polyethylene glycol shows promise in spinal cord tissue engineering applications. Although studies have examined repairing spinal cord injury with polyethylene glycol, these compelling findings have not been recently reviewed or evaluated as a whole. Thus, we herein review and summarize the findings of studies conducted both within and beyond China that have examined the repair of spinal cord injury using polyethylene glycol. The following summarizes the results of studies using polyethylene glycol alone as well as coupled with polymers or hydrogels: (1) polyethylene glycol as an adjustable biomolecule carrier resists nerve fiber degeneration, reduces the inflammatory response, inhibits vacuole and scar formation, and protects nerve membranes in the acute stage of spinal cord injury. (2) Polyethylene glycol-coupled polymers not only promote angiogenesis but also carry drugs or bioactive molecules to the injury site. Because such polymers cross both the blood-spinal cord and blood-brain barriers, they have been widely used as drug carriers. (3) Polyethylene glycol hydrogels have been used as supporting substrates for the growth of stem cells after injury, inducing cell migration, proliferation, and differentiation. Simultaneously, polyethylene glycol hydrogels isolate or reduce local glial scar invasion, promote and guide axonal regeneration, cross the transplanted area, and re-establish synaptic connections with target tissue, thereby promoting spinal cord repair. On the basis of the reviewed studies, we conclude that polyethylene glycol is a promising synthetic material for use in the repair of spinal cord injury.

Key words: nerve regeneration, spinal cord injury, polyethylene glycol, nerve tissue engineering, biomaterials, spinal nerve repair, biological drug, blood-spinal cord barrier, neural stem cells, carrier, cell culture, neural regeneration