中国神经再生研究(英文版)

中国神经再生研究(英文版) ›› 2017, Vol. 12 ›› Issue (10): 1640-1647.doi: 10.4103/1673-5374.217339

• 原著:脑损伤修复保护与再生 • 上一篇    下一篇

注意缺陷多动障碍与正常发育患者年龄相关的脑网络连接差异：静息态功能MRI研究

  

  • 收稿日期:2017-09-19 出版日期:2017-10-15 发布日期:2017-10-15
  • 基金资助:

     韩国基础科学研究所基金；韩国国家研究基金

Age-related connectivity differences between attention deficit and hyperactivity disorder patients and typically developing subjects: a resting-state functional MRI study

Jisu Hong1, 2, Bo-yong Park1, 2, Hwan-ho Cho1, 2, Hyunjin Park2, 3   

  1. 1 Department of Electronic, Electrical and Computer Engineering, Sungkyunkwan University, Suwon, Korea
    2 Center for Neuroscience Imaging Research (CNIR), Institute for Basic Science, Suwon, Korea
    3 School of Electronic and Electrical Engineering, Sungkyunkwan University, Suwon, Korea
  • Received:2017-09-19 Online:2017-10-15 Published:2017-10-15
  • Contact: Hyunjin Park, Ph.D.,hyunjinp@skku.edu.
  • Supported by:

    This work was supported by the Institute for Basic Science [grant No. IBS-R015-D1] and the National Research Foundation of Korea(grant No. NRF-2016R1A2B4008545).

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摘要：

注意缺陷多动障碍是一种注意力无法集中、过度活跃、无法控制行为的精神失调。对儿童注意缺陷多动障碍不管治疗与否，其中相当一部分到了成人仍然遗留有症状，其属于慢性神经系统发育障碍，受脑网络复杂的相互作用影响。我们应用静息态功能磁共振对儿童、青少年、成人3个年龄段的注意缺陷多动障碍和正常发育受试者间年龄相关的脑网络差异进行了研究。共收集184名受试者的静息态功能磁共振资料，包括儿童、青少年、成人注意缺陷多动障碍患者27，32，31例，对应的正常发育受试者分别为31，32，31名。首先应用脑网络组图谱确定网络分析节点，然后比较3个年龄段的注意缺陷多动障碍和正常发育受试者节点中心度，以确定可解释年龄相关脑网络差异的脑区。多个脑区显示出明显的疾病状态与年龄间的相互作用，其中左侧额下回、左侧颞中回和左侧岛回与认知功能有关，且以左侧颞中回作用最为明显。说明认知相关脑区的异常发育可能与注意缺陷多动障碍患者年龄相关的大脑网络改变有关，作者认为该结果有助于深入理解脑功能如何影响注意缺陷多动障碍症状。

orcid:0000-0001-5681-8918(Hyunjin Park)

关键词: 神经再生, 神经科学, 注意缺陷多动障碍, 认知功能, 网络连接, 静息态功能磁共振, 脑网络组图谱, 全脑分析, 疾病-年龄相互作用

Abstract:

Attention deficit and hyperactivity disorder (ADHD) is a disorder characterized by behavioral symptoms including hyperactivity/impulsivity among children, adolescents, and adults. These ADHD related symptoms are influenced by the complex interaction of brain networks which were under explored. We explored age-related brain network differences between ADHD patients and typically developing (TD) subjects using resting state fMRI (rs-fMRI) for three age groups of children, adolescents, and adults. We collected rs-fMRI data from 184 individuals (27 ADHD children and 31 TD children; 32 ADHD adolescents and 32 TD adolescents;and 31 ADHD adults and 31 TD adults). The Brainnetome Atlas was used to define nodes in the network analysis. We compared three age groups of ADHD and TD subjects to identify the distinct regions that could explain age-related brain network differences based on degree centrality, a well-known measure of nodal centrality. The left middle temporal gyrus showed significant interaction effects between disease status (i.e., ADHD or TD) and age (i.e., child, adolescent, or adult) (P < 0.001). Additional regions were identified at a relaxed threshold (P < 0.05). Many of the identified regions (the left inferior frontal gyrus, the left middle temporal gyrus, and the left insular gyrus) were related to cognitive function. The results of our study suggest that aberrant development in cognitive brain regions might be associated with age-related brain network changes in ADHD patients. These findings contribute to better understand how brain function influences the symptoms of ADHD.

Key words: nerve regeneration, attention deficit and hyperactivity disorder, cognitive function, connectivity, resting-state fMRI, Brainnetome Atlas, whole brain analysis, disease-aging interaction effect, neuroscience, neural regeneration