中国神经再生研究(英文版) ›› 2017, Vol. 12 ›› Issue (11): 1918-1926.doi: 10.4103/1673-5374.219055

• 综述:脑损伤修复保护与再生 • 上一篇    下一篇

人脑胶质瘤干细胞研究在中国

  

  • 收稿日期:2017-07-31 出版日期:2017-11-15 发布日期:2017-11-15
  • 基金资助:

    中国国家自然科学基金项目(81172400, 81101909, 81272793, 81302180, 81302196, 81472739)

Research on human glioma stem cells in China

Yao-dong Zhao1, 2, Quan-bin Zhang1, 3, Hua Chen1, 4, Xi-feng Fei1, 5, Yun-tian Shen1, Xiao-yan Ji1, Jia-wei Ma1, Ai-dong Wang1, Jun Dong1, Qing Lan1, Qiang Huang1   

  1. 1 Department of Neurosurgery and Brain Tumor Research Laboratory, Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu Province,China
    2 Shanghai General Hospital, Shanghai, China
    3 Shanghai 10th People’s Hospital, Shanghai, China
    4 Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu Province, China
    5 Suzhou Kowloon Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
  • Received:2017-07-31 Online:2017-11-15 Published:2017-11-15
  • Contact: Qiang Huang, M.D.,hq1936@163.com.
  • Supported by:

    This study was supported by the National Natural Science Foundation of China, No. 81172400, 81101909, 81272793, 81302180,81302196, 81472739.

摘要:

人胶质瘤干细胞的研究开始于21世纪初,并且逐年快速发展。文章对人胶质瘤干细胞培养技术、分子调控、信号传导通路、癌症治疗、微环境和干细胞来源与功能,尤其是中国在此方面的研究情况作以综述介绍。作者既往研究发现在一定条件下,神经干细胞、胶质细胞和胶质瘤干细胞可以相互转化。基于人脑胶质瘤干细胞研究的国际化背景,作者愿与所有研究者分享人胶质瘤干细胞的发现。

orcid:0000-0001-6584-9230(Qiang Huang)

关键词: 神经再生, 胶质瘤干细胞, 中国, 细胞培养, 生物学特性, 细胞来源, 细胞功能, 微环境, 分子靶向疗法, 化疗, 放疗

Abstract:

Research on human glioma stem cells began early in the 21st century and since then has become a rapidly growing research field with the number of publications increasing year by year. The research conducted by our diverse group of investigators focused primarily on cell culture techniques, molecular regulation, signaling pathways, cancer treatment, the stem cell microenvironment and the cellular origin and function of glioma stem cells. In particular, we put forward our view that there are inverse or forward transformations among neural stem cells, glial cells and glioma stem cells in glioma tissues under certain conditions. Based on the background of the progress of international research on human glioma stem cells, we aim to share our progress and current findings of human glioma stem cell research in China with colleagues around the world.

Key words: nerve regeneration, glioma stem cells, China, cell culture, molecular characteristics, cellular origin, cell function, microenvironment, molecular targeted therapy, chemotherapy, radiotherapy, neural regeneration