中国神经再生研究(英文版) ›› 2018, Vol. 13 ›› Issue (12): 2067-2072.doi: 10.4103/1673-5374.241444

• 综述:神经损伤修复保护与再生 • 上一篇    下一篇

小胶质细胞中微小RNA可对抗中枢神经系统疾病

  

  • 收稿日期:2018-08-11 出版日期:2018-12-15 发布日期:2018-12-15
  • 基金资助:

    国家自然科学基金资助(81401084)(XHW);北京市医院规划管理局(DFL 20150802)(TLW);北京215名高级保健人才计划学术带头人计划(第008-0027号)(TLW);北京市卫生和计划生育委员会项目(2008-0027,PXM 2017_026283_000002)(TLW);北京市医院临床医学发展专项基金(ZYLX 201706)(TLW)

MicroRNAs of microglia: wrestling with central nervous system disease

Xiao-Hua Wang1, 2, 3, Tian-Long Wang1, 2, 3   

  1. 1 Department of Anesthesiology, Xuanwu Hospital, Capital Medical University, Beijing, China
    2 Institute of Geriatrics, Beijing, China
    3 National Clinical Research Center for Geriatric Disorders, Beijing, China
  • Received:2018-08-11 Online:2018-12-15 Published:2018-12-15
  • Contact: Tian-Long Wang, w_tl5595@yahoo.com.
  • Supported by:

    This work was supported by the National Natural Science Foundation of China, No. 81401084 (to XHW); Beijing Municipal Administration of Hospital Ascent Plan, No. DFL20150802 (to TLW); Beijing 215 High Level Healthcare Talent Plan Academic Leader, No.008-0027 (to TLW); Beijing Municipal Commission of Health and Family Planning, No. PXM2017_026283_000002 (to TLW); Beijing Municipal Administration of Hospitals Clinical Medicine Development of Special Funding, No. ZYLX201706 (to TLW).

摘要:

小胶质细胞作为大脑常住髓系细胞,可对脑发育、脑缺血、神经退行性变和神经病毒感染有一定影响,通过转录后调控的微小RNA在中枢神经系统疾病中起着关键作用。许多证据显示,微小RNA是一种重要的调节介导剂,可影响小胶质细胞激活、极化和自噬,随后影响到神经易燃和中枢神经系统疾病的结果。本文综述了小胶质细胞相关中枢神经系统功能障碍的研究进展,认为功能微小RNA是一种具有吸引力的治疗小胶质细胞相关中枢神经系统功能障碍的策略和有力的治疗手段。文章还阐述了多功能微小RNA对抗中枢神经系统疾病的最新研究成果。

orcid:0000-0003-1636-0142(Tian-Long Wang)

关键词: 小胶质细胞, 神经变性, 中枢神经系统疾病, 微小RNA, 激活, 极化, 自噬, 神经再生, 治疗

Abstract:

Microglia serve as brain-resident myeloid cells that affect cerebral development, ischemia, neurodegeneration, and neuro-viral infection. MicroRNAs play a key role in central nervous system disease through post-transcriptional regulation. Indeed, evidence shows that microRNAs are one of the most important regulators mediating microglial activation, polarization, and autophagy, and subsequently affecting neuroinflammation and the outcome of central nervous system disease. In this review, we provide insight into the function of microRNAs, which may be an attractive strategy and influential treatment for microglia-related central nervous system dysfunction. Moreover, we comprehensively describe how microglia fight against central nervous system disease via multiple functional microRNAs.

Key words: microglia, neurodegeneration, central nervous system disease, microRNAs, activation, polarization, autophagy, neural regeneration