中国神经再生研究(英文版)

中国神经再生研究(英文版) ›› 2019, Vol. 14 ›› Issue (6): 954-961.doi: 10.4103/1673-5374.250569

• 综述:脑损伤修复保护与再生 • 上一篇    下一篇

自噬：电针治疗脑缺血再灌注损伤的靶点新见解

  

  • 出版日期:2019-06-15 发布日期:2019-06-15

Autophagy: novel insights into therapeutic target of electroacupuncture against cerebral ischemia/reperfusion injury

Ya-Guang Huang 1 , Wei Tao 1 , Song-Bai Yang 2 , Jin-Feng Wang 1 , Zhi-Gang Mei 1, 2 , Zhi-Tao Feng 1   

  1. 1 Medical College of China Three Gorges University, Yichang, Hubei Province, China
    2 Yichang Hospital of Traditional Chinese Medicine, Clinical Medical College of Traditional Chinese Medicine, China Three Gorges University, Yichang, Hubei Province, China
  • Online:2019-06-15 Published:2019-06-15
  • Contact: Zhi-Gang Mei, MD, meizhigang@ctgu.edu.cn; Zhi-Tao Feng, MD, fengzhitao2008@126.com.

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摘要：

电针被认为是缺血性脑血管病的有效辅助治疗手段，但其潜在机制仍然不明。自噬是细胞存活和死亡的必要条件，有研究认为其可参与脑缺血再灌注损伤的过程，并可能在电针治疗中起关键作用。作者从自噬的角度为电针对脑缺血再灌注损伤的治疗靶点提供了新的见解。文章总结了有关电针治疗脑缺血再灌注损伤过程中调节自噬相关标志物ULK1、Beclin1、微管相关蛋白1轻链3、p62以及自噬体等的研究进展。表明电针可能对自噬起始、自噬体成核、自噬体的扩张和成熟以及自噬体的融合和降解等方面都产生重要的影响。此外有研究显示电针可能通过激活mTOR信号通路来调节自噬。此次综述将为探索电针治疗缺血性脑血管疾病的自噬相关靶点提供帮助。

orcid: 0000-0002-9099-7099 (Zhi-Gang Mei)
           0000-0003-1107-944X (Zhi-Tao Feng)

关键词: 自噬, 电针, 脑缺血再灌注, 神经保护, mTOR, LC3, Beclin1, p62, 神经再生

Abstract:

Electroacupuncture is known as an effective adjuvant therapy in ischemic cerebrovascular disease. How¬ever, its underlying mechanisms remain unclear. Studies suggest that autophagy, which is essential for cell survival and cell death, is involved in cerebral ischemia reperfusion injury and might be modulate by elec¬troacupuncture therapy in key ways. This paper aims to provide novel insights into a therapeutic target of electroacupuncture against cerebral ischemia/reperfusion injury from the perspective of autophagy. Here we review recent studies on electroacupuncture regulation of autophagy-related markers such as UNC-51- like kinase-1 complex, Beclin1, microtubule-associated protein-1 light chain 3, p62, and autophagosomes for treating cerebral ischemia/reperfusion injury. The results of these studies show that electroacupuncture may affect the initiation of autophagy, vesicle nucleation, expansion and maturation of autophagosomes, as well as fusion and degradation of autophagolysosomes. Moreover, studies indicate that electroacupuncture probably modulates autophagy by activating the mammalian target of the rapamycin signaling pathway. This review thus indicates that autophagy is a therapeutic target of electroacupuncture treatment against ischemic cerebrovascular diseases.

Key words: nerve regeneration, autophagy, electroacupuncture, cerebral ischemia reperfusion injury, mTOR, LC3, Beclin1, p62, neuroprotection, neural regeneration