中国神经再生研究(英文版)

中国神经再生研究(英文版) ›› 2024, Vol. 19 ›› Issue (3): 598-605.doi: 10.4103/1673-5374.380872

• 综述:周围神经损伤修复保护与再生 • 上一篇    下一篇

糖尿病周围神经病变病理生理变化中的细胞代谢

  

  • 出版日期:2024-03-15 发布日期:2023-09-02
  • 基金资助:
    国家重点研发计划项目（2021YFC2400803，2021YFC2 400801）；国家自然科学基金项目（82002290，82072452，82272475）；青年人才托举工程项目（YESS20200153）；中德流动计划项目（M-0699）；上海市第六人民医院优秀青年培养计划项目（ynyq202201）；上海远航项目（20YF1436000）；上海科技大学医学工程合作项目（10-22-310-520）；上海市卫生健康委员会项目（202040399）

Cell metabolism pathways involved in the pathophysiological changes of diabetic peripheral neuropathy

Yaowei Lv1, 2, #, Xiangyun Yao1, 2, 3, #, Xiao Li1, 2, 4, Yuanming Ouyang1, 2, 3, Cunyi Fan1, 2, 3, Yun Qian1, 2, 3, *   

  1. 1Department of Orthopedics, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China; 2Shanghai Engineering Research Center for Orthopaedic Material Innovation and Tissue Regeneration, Shanghai, China; 3Youth Science and Technology Innovation Studio of Shanghai Jiao Tong University School of Medicine, Shanghai, China; 4College of Fisheries and Life Science, Shanghai Ocean University, Shanghai, China
  • Online:2024-03-15 Published:2023-09-02
  • Contact: Yun Qian, MD, lollipopcloudland@foxmail.com.
  • Supported by:
    This work was supported by the Projects of the National Key R&D Program of China, Nos. 2021YFC2400803 (to YO), 2021YFC2400801 (to YQ); the National Natural Science Foundation of China, Nos. 82002290 (to YQ), 82072452 (to YO), 82272475 (to YO); the Young Elite Scientist Sponsorship Program by Cast, No. YESS20200153 (to YQ); the Sino-German Mobility Programme, No. M-0699 (to YQ); the Excellent Youth Cultivation Program of Shanghai Sixth People’s Hospital, No. ynyq202201 (to YQ); the Shanghai Sailing Program, No. 20YF1436000 (to YQ); the Medical Engineering Co-Project of University of Shanghai for Science and Technology, 10-22-310-520 (to YO); and a grant from Shanghai Municipal Health Commission, No. 202040399 (to YO).

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摘要：

糖尿病周围神经病变是糖尿病常见并发症之一。现有的糖尿病周围神经病变疗法尚不能满足其复杂的治疗需要，且尚无方法被证实能治疗糖尿病周围神经病变。由于对糖尿病周围神经病变能量代谢变化和相关信号通路缺乏全面的了解，因此，探索糖尿病周围神经病变能量变化和代谢改变可能成为开发糖尿病周围神经病变治疗方法的机会。此次综述从细胞代谢角度总结了糖尿病周围神经病变的病理生理机制进程，并概括了针对不同代谢通路的特异性干预手段，旨在开发针对糖尿病周围神经病变的有效治疗方法。

https://orcid.org/0000-0003-1600-5693 (Yun Qian); https://orcid.org/0000-0002-8411-3920 (Xiangyun Yao); https://orcid.org/0000-0002-5269-4548 (Yaowei Lv); 
https://orcid.org/0000-0002-2583-4066 (Xiao Li); https://orcid.org/0000-0002-6298-7133 (Yuanming Ouyang); https://orcid.org/0000-0002-7854-5233 (Cunyi Fan)

关键词: 糖尿病周围神经病变, 周围神经损伤, 细胞代谢

Abstract: Diabetic peripheral neuropathy is a common complication of diabetes mellitus. Elucidating the pathophysiological metabolic mechanism impels the generation of ideal therapies. However, existing limited treatments for diabetic peripheral neuropathy expose the urgent need for cell metabolism research. Given the lack of comprehensive understanding of energy metabolism changes and related signaling pathways in diabetic peripheral neuropathy, it is essential to explore energy changes and metabolic changes in diabetic peripheral neuropathy to develop suitable treatment methods. This review summarizes the pathophysiological mechanism of diabetic peripheral neuropathy from the perspective of cellular metabolism and the specific interventions for different metabolic pathways to develop effective treatment methods. Various metabolic mechanisms (e.g., polyol, hexosamine, protein kinase C pathway) are associated with diabetic peripheral neuropathy, and researchers are looking for more effective treatments through these pathways.

Key words: cell metabolism, diabetic peripheral neuropathy, peripheral nerve injury, protein kinase C pathway, reactive oxygen species