中国神经再生研究(英文版)

中国神经再生研究(英文版) ›› 2013, Vol. 8 ›› Issue (27): 2520-2530.doi: 10.3969/j.issn.1673-5374.2013.27.003

• 原著:周围神经损伤修复保护与再生 • 上一篇    下一篇

丙泊酚对损失坐骨神经是损伤还是保护？

  

  • 收稿日期:2013-06-05 修回日期:2013-08-03 出版日期:2013-09-25 发布日期:2013-09-25
  • 基金资助:

    内蒙古科技厅基金资助项目（Y2011024007）

Propofol’s effect on the sciatic nerve Harmful or protective?

Yi Sun, Xizhe Zhang, Qi Zhou, Yong’an Wang, Yiwen Jiang, Jian Cao   

  1. Chifeng Municipal Hospital, Chifeng 024000, Inner Mongolia Autonomous Region, China
  • Received:2013-06-05 Revised:2013-08-03 Online:2013-09-25 Published:2013-09-25
  • Contact: Jian Cao, M.D., Associate chief physician, Chifeng Municipal Hospital, Chifeng 024000, Inner Mongolia Autonomous Region, China, caojian2005088@ hotmail.com.
  • About author:Yi Sun, Professor, Chief physician, Master’s supervisor. Yi Sun and Xizhe Zhang contributed equally to this work.
  • Supported by:

    This study was financially supported by the Science and Technology Bureau of Inner Mongolia Autonomous Region, No. Y2011024007.

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摘要：

丙泊酚具有抑制炎性反应，抑制星形胶质细胞分泌促炎性细胞因子的合成，阻断促炎性细胞因子的伤害性作用。鉴于此，实验对坐骨神经损伤小鼠坐骨神经损伤部位注射丙泊酚后，观察到损伤侧L4-6段脊髓中核因子κB表达减少，细胞凋亡减少，神经髓鞘损伤减轻，神经肌电传导阻滞恢复。由此说明丙泊酚可能通过抑制周围神经损伤后的炎性免疫反应，降低脊髓细胞核因子κB的表达，减少细胞凋亡，促进坐骨神经的修复。

关键词: 神经再生, 周围神经损伤, 丙泊酚, 核因子κB, 坐骨神经损伤, 炎性反应, 神经肌电传导, 周围神经损伤, 免疫抑制, 髓鞘, 基金资助文章

Abstract:

Propofol can inhibit the inflammatory response and reduce the secretion and harmful effects of as-trocyte-derived proinflammatory cytokines. In this study, after propofol was injected into the injured sciatic nerve of mice, nuclear factor kappa B expression in the L4–6 segments of the spinal cord in the injured side was reduced, apoptosis was decreased, nerve myelin defects were alleviated, and the nerve conduction block was lessened. The experimental findings indicate that propofol inhibits the inflammatory and immune responses, decreases the expression of nuclear factor kappa B, and reduces apoptosis. These effects of propofol promote regeneration following sciatic nerve injury.

Key words: neural regeneration, peripheral nerve injury, propofol, nuclear factor kappa B, sciatic nerve injury, inflammatory response, nerve conduction, immunosuppression, myelin sheath, grant-supported paper, neuroregeneration